Vimovo and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Vimovo (esomeprazole magnesium; naproxen), especially for people who are female, 60+ old, also take Enbrel, and have High blood pressure.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Vimovo. It is created by eHealthMe based on reports of 9,495 people who have side effects when taking Vimovo from the FDA, and is updated regularly.

What is Vimovo?

Vimovo has active ingredients of esomeprazole magnesium; naproxen. It is often used in osteoarthritis. eHealthMe is studying from 9,608 Vimovo users. Check the latest studies of Vimovo.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,228 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 08, 2026

9,495 people reported to have side effects when taking Vimovo.
Among them, 15 people (0.16%) have Knee joint replacement.

Could Vimovo cause Knee joint replacement?

Among these 15 people:

What is the gender of people who have Knee joint replacement when taking Vimovo? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Knee joint replacement when taking Vimovo? *

What are other drugs people take besides Vimovo? *

What are other side effects people have besides Knee joint replacement? *

Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 4 people, 26.67%
Impaired Healing: 4 people, 26.67%
Drug Intolerance (drug sensitivity): 4 people, 26.67%
Dizziness: 4 people, 26.67%
Fall: 3 people, 20.00%
Joint Pain: 3 people, 20.00%
Depression: 3 people, 20.00%
Hand Deformity: 2 people, 13.33%
Fracture Delayed Union (delayed cure of broken bone): 2 people, 13.33%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 13.33%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 20.00%
High Blood Pressure: 3 people, 20.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 13.33%
Fever: 2 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 13.33%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 13.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 13.33%
Headache (pain in head): 2 people, 13.33%
Inflammation: 2 people, 13.33%
Osteopenia (a condition where bone mineral density is lower than normal): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Vimovo and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vimovo:

Vimovo (9,608 reports)

Knee joint replacement treatments and more:

Knee joint replacement (26,755 reports)

How severe was Knee joint replacement and when was it recovered:

Knee joint replacement in Vimovo

Expand to all the drugs that have ingredients of esomeprazole magnesium; naproxen:

Knee joint replacement and drugs with ingredients of esomeprazole magnesium; naproxen (2 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vimovo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (953 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,228 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on esomeprazole magnesium; naproxen (the active ingredients of Vimovo) and Vimovo (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.