Vioxx and Muscle rupture - a phase IV clinical study of FDA data

Summary:

Muscle rupture is reported as a side effect among people who take Vioxx (rofecoxib), especially for people who are male, 50-59 old, have been taking the drug for 1 - 2 years also take Ativan, and have Intervertebral disc protrusion.

The phase IV clinical study analyzes which people have Muscle rupture when taking Vioxx. It is created by eHealthMe based on reports of 110,097 people who have side effects when taking Vioxx from the FDA, and is updated regularly.

What is Vioxx?

Vioxx has active ingredients of rofecoxib. It is often used in arthritis. eHealthMe is studying from 110,130 Vioxx users. Check the latest studies of Vioxx.

What is Muscle rupture?

Muscle rupture (tear in muscle) is found to be associated with 397 drugs and 508 conditions by eHealthMe. Check the latest studies of Muscle rupture.

On Jul, 13, 2026

110,097 people reported to have side effects when taking Vioxx.
Among them, 15 people (0.01%) have Muscle rupture.

Among these 15 people:

How long have people been on Vioxx when they have Muscle rupture? *

What is the gender of people who have Muscle rupture when taking Vioxx? *

female: 26.67 %
male: 73.33 %

What is the age of people who have Muscle rupture when taking Vioxx? *

What are other drugs people take besides Vioxx? *

What are other side effects people have besides Muscle rupture? *

Varicose Vein (veins that have become enlarged and tortuous): 5 people, 33.33%
Post Thrombotic Syndrome (long-term effects that can occur after venous thrombosis): 5 people, 33.33%
Thrombosis (formation of a blood clot inside a blood vessel): 5 people, 33.33%
Compartment Syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels): 5 people, 33.33%
Eye Disorder: 2 people, 13.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 13.33%
Heart Attack: 2 people, 13.33%
Arthropathy: 2 people, 13.33%
Haematoma (collection of blood outside the blood vessels): 2 people, 13.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 13.33%

What are the existing conditions these people have? *

Intervertebral Disc Protrusion (spinal disc protrusion): 5 people, 33.33%
Pneumonia: 2 people, 13.33%
Shoulder Pain: 1 person, 6.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.67%
Joint Pain: 1 person, 6.67%
Inflammation: 1 person, 6.67%
Arthritis Bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Vioxx and have Muscle rupture?

- Check whether Muscle rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vioxx:

Vioxx (110,130 reports)

Muscle rupture treatments and more:

Muscle rupture (4,655 reports)

Browse all side effects of Vioxx:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rupture:

Muscle rupture (397 drugs)

Browse all the conditions that are associated with Muscle rupture:

Muscle rupture (508 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on rofecoxib (the active ingredients of Vioxx) and Vioxx (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.