Vitamin d and Necrosis - a phase IV clinical study of FDA data

Summary:

Necrosis is reported as a side effect among people who take Vitamin d (ergocalciferol), especially for people who are female, 60+ old, also take Calcium, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Necrosis when taking Vitamin d. It is created by eHealthMe based on reports of 282,675 people who have side effects when taking Vitamin d from the FDA, and is updated regularly.

What is Vitamin d?

Vitamin d has active ingredients of ergocalciferol. It is often used in low vitamin d. eHealthMe is studying from 294,095 Vitamin d users. Check the latest studies of Vitamin d.

What is Necrosis?

Necrosis (the death of body tissue) is found to be associated with 751 drugs and 969 conditions by eHealthMe. Check the latest studies of Necrosis.

On Aug, 05, 2026

282,675 people reported to have side effects when taking Vitamin d.
Among them, 85 people (0.03%) have Necrosis.

Among these 85 people:

What is the gender of people who have Necrosis when taking Vitamin d? *

female: 81.71 %
male: 18.29 %

What is the age of people who have Necrosis when taking Vitamin d? *

What are other drugs people take besides Vitamin d? *

What are other side effects people have besides Necrosis? *

Pain In Jaw: 22 people, 25.88%
Osteonecrosis Of Jaw (death of bone of jaw): 20 people, 23.53%
Oral Pain: 19 people, 22.35%
Gastroenteritis (inflammation of stomach and intestine): 18 people, 21.18%
Joint Pain: 18 people, 21.18%
Oral Herpes (viral infection of mouth): 18 people, 21.18%
Herpes Simplex (herpes simplex is a common viral infection): 17 people, 20.00%
Periodontitis (inflammation of the tissue around the teeth): 16 people, 18.82%
Pain: 16 people, 18.82%
Periodontal Disease (disease that attacks the gum and bone and around the teeth): 16 people, 18.82%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 26 people, 30.59%
High Blood Pressure: 25 people, 29.41%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 17 people, 20.00%
Oral Herpes (viral infection of mouth): 17 people, 20.00%
Pain: 7 people, 8.24%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.88%
Depression: 5 people, 5.88%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 5.88%
Breast Cancer Metastatic: 5 people, 5.88%
Multiple Myeloma (cancer of the plasma cells): 4 people, 4.71%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin d and have Necrosis?

- Check whether Necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin d:

Vitamin d (294,095 reports)

Necrosis treatments and more:

Necrosis (8,274 reports)

Browse all side effects of Vitamin d:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Necrosis:

Necrosis (751 drugs)

Browse all the conditions that are associated with Necrosis:

Necrosis (969 conditions)

Related publications that referenced our studies

Kapoor S, "Influence of Vitamin D Consumption and Levels on the Development of Psychiatric Disorders", Lee, Y. J., & Park, K. (2018). Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension.?Drug safety-case reports,?5(1), 7., 2014 Aug .
Kapoor S, "Influence of Vitamin D Consumption and Levels on the Development of Psychiatric Disorders", Lee, Y. J., & Park, K. (2018). Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension.?Drug safety-case reports,?5(1), 7., 2014 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on ergocalciferol (the active ingredients of Vitamin d) and Vitamin d (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.