Vitamin d2 and Peripheral swelling - a phase IV clinical study of FDA data

Summary:

Peripheral swelling is reported as a side effect among people who take Vitamin d2 (ergocalciferol), especially for people who are female, 60+ old, also take Vitamin B12, and have Polycythaemia vera.

The phase IV clinical study analyzes which people have Peripheral swelling when taking Vitamin d2. It is created by eHealthMe based on reports of 839 people who have side effects when taking Vitamin d2 from the FDA, and is updated regularly.

What is Vitamin d2?

Vitamin d2 has active ingredients of ergocalciferol. eHealthMe is studying from 979 Vitamin d2 users. Check the latest studies of Vitamin d2.

What is Peripheral swelling?

Peripheral swelling is found to be associated with 2,181 drugs and 1,743 conditions by eHealthMe. Check the latest studies of Peripheral swelling.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

839 people reported to have side effects when taking Vitamin d2.
Among them, 18 people (2.15%) have Peripheral swelling.

Could Vitamin d2 cause Peripheral swelling?

Among these 18 people:

What is the gender of people who have Peripheral swelling when taking Vitamin d2? *

female: 73.33 %
male: 26.67 %

What is the age of people who have Peripheral swelling when taking Vitamin d2? *

What are other drugs people take besides Vitamin d2? *

What are other side effects people have besides Peripheral swelling? *

Fatigue (feeling of tiredness): 7 people, 38.89%
Dyspnea (difficult or laboured breathing): 6 people, 33.33%
Pain In Extremity: 5 people, 27.78%
Diarrhea: 4 people, 22.22%
Headache (pain in head): 4 people, 22.22%
Fall: 4 people, 22.22%
Weight Increased: 4 people, 22.22%
Weakness: 4 people, 22.22%
Abdominal Distension: 3 people, 16.67%
Head Injury: 3 people, 16.67%

What are the existing conditions these people have? *

Pain: 2 people, 11.11%
High Blood Cholesterol: 2 people, 11.11%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 2 people, 11.11%
Dizziness: 1 person, 5.56%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 1 person, 5.56%
Hypersensitivity: 1 person, 5.56%
High Blood Pressure: 1 person, 5.56%
Herniated Nucleus Pulposus (Slipped Disk): 1 person, 5.56%
Heart Rate Increased: 1 person, 5.56%
Hallucinations (sensations that appear real but are created by your mind): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin d2 and have Peripheral swelling?

- Check whether Peripheral swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin d2:

Vitamin d2 (979 reports)

Browse all side effects of Vitamin d2:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Peripheral swelling:

Peripheral swelling (2,181 drugs)

Browse all the conditions that are associated with Peripheral swelling:

Peripheral swelling (1,743 conditions)

Related publications that referenced our studies

Kapoor S, "Influence of Vitamin D Consumption and Levels on the Development of Psychiatric Disorders", Lee, Y. J., & Park, K. (2018). Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension.?Drug safety-case reports,?5(1), 7., 2014 Aug .
Kapoor S, "Influence of Vitamin D Consumption and Levels on the Development of Psychiatric Disorders", Lee, Y. J., & Park, K. (2018). Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension.?Drug safety-case reports,?5(1), 7., 2014 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on ergocalciferol (the active ingredients of Vitamin d2) and Vitamin d2 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.