Vivelle-dot and Ddd - a phase IV clinical study of FDA data

Summary:

Ddd is reported as a side effect among people who take Vivelle-dot (estradiol), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Cymbalta, and have Bone density abnormal.

The phase IV clinical study analyzes which people have Ddd when taking Vivelle-dot. It is created by eHealthMe based on reports of 3,271 people who have side effects when taking Vivelle-dot from the FDA, and is updated regularly.

What is Vivelle-dot?

Vivelle-dot has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,545 Vivelle-dot users. Check the latest studies of Vivelle-dot.

What is Ddd?

Ddd is found to be associated with 1,308 drugs and 1,419 conditions by eHealthMe. Check the latest studies of Ddd.

On Jul, 18, 2026

3,271 people reported to have side effects when taking Vivelle-dot.
Among them, 22 people (0.67%) have Ddd.

Among these 22 people:

How long have people been on Vivelle-dot when they have Ddd? *

What is the gender of people who have Ddd when taking Vivelle-dot? *

female: 77.27 %
male: 22.73 %

What is the age of people who have Ddd when taking Vivelle-dot? *

What are other drugs people take besides Vivelle-dot? *

What are other side effects people have besides Ddd? *

Pain: 16 people, 72.73%
Neck Pain: 16 people, 72.73%
Back Pain: 15 people, 68.18%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 15 people, 68.18%
Drowsiness: 14 people, 63.64%
Osteonecrosis Of Jaw (death of bone of jaw): 14 people, 63.64%
Chest Pain: 14 people, 63.64%
Neuropathy Peripheral (surface nerve damage): 14 people, 63.64%
Depression: 14 people, 63.64%
Toothaches (tooth pain): 14 people, 63.64%

What are the existing conditions these people have? *

Bone Density Abnormal: 7 people, 31.82%
Osteoporosis (bones weak and more likely to break): 6 people, 27.27%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 4.55%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 4.55%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 4.55%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Vivelle-dot and have Ddd?

- Check whether Ddd is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vivelle-dot:

Vivelle-dot (3,545 reports)

Ddd treatments and more:

Ddd (19,910 reports)

Browse all side effects of Vivelle-dot:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ddd:

Ddd (1,308 drugs)

Browse all the conditions that are associated with Ddd:

Ddd (1,419 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Vivelle-dot) and Vivelle-dot (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.