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Vivelle-dot and Urticaria - a phase IV clinical study of FDA data

Summary:

Urticaria is reported as a side effect among people who take Vivelle-dot (estradiol), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Kenalog, and have Joint pain.

The phase IV clinical study analyzes which people have Urticaria when taking Vivelle-dot. It is created by eHealthMe based on reports of 3,271 people who have side effects when taking Vivelle-dot from the FDA, and is updated regularly.

What is Vivelle-dot?

Vivelle-dot has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,545 Vivelle-dot users. Check the latest studies of Vivelle-dot.

What is Urticaria?

Urticaria (rash of round, red welts on the skin that itch intensely) is found to be associated with 2,622 drugs and 2,952 conditions by eHealthMe. Check the latest studies of Urticaria.

On Jul, 15, 2026

3,271 people reported to have side effects when taking Vivelle-dot.
Among them, 63 people (1.93%) have Urticaria.

Could Vivelle-dot cause Urticaria?

Among these 63 people:

How long have people been on Vivelle-dot when they have Urticaria? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Urticaria when taking Vivelle-dot? *

  • female: 98.21 %
  • male: 1.79 %

What is the age of people who have Urticaria when taking Vivelle-dot? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 8.33 %
  • 30-39: 0.0 %
  • 40-49: 20.83 %
  • 50-59: 50.0 %
  • 60+: 20.83 %

What are other drugs people take besides Vivelle-dot? *

  1. Fish Oil: 10 people, 15.87%
  2. Kenalog: 10 people, 15.87%
  3. Zyrtec: 9 people, 14.29%
  4. Miralax: 8 people, 12.70%
  5. Magnesium: 8 people, 12.70%
  6. Jakafi: 8 people, 12.70%
  7. Imitrex: 8 people, 12.70%
  8. Calcium: 7 people, 11.11%
  9. Hydrea: 7 people, 11.11%
  10. Vitamin D3: 7 people, 11.11%

What are other side effects people have besides Urticaria? *

  1. Itching: 18 people, 28.57%
  2. Rashes (redness): 16 people, 25.40%
  3. Feeling Abnormal: 15 people, 23.81%
  4. Insomnia (sleeplessness): 15 people, 23.81%
  5. Headache (pain in head): 12 people, 19.05%
  6. Joint Pain: 12 people, 19.05%
  7. Dizziness: 10 people, 15.87%
  8. Rash Erythematous (redness of the skin): 10 people, 15.87%
  9. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 9 people, 14.29%
  10. Diarrhea: 9 people, 14.29%

What are the existing conditions these people have? *

  1. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 8 people, 12.70%
  2. Joint Pain: 8 people, 12.70%
  3. Primary Myelofibrosis (primary disorder of the bone marrow): 7 people, 11.11%
  4. Bone Pain: 6 people, 9.52%
  5. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 7.94%
  6. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 7.94%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 4.76%
  8. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 4.76%
  9. Urinary Tract Infection: 2 people, 3.17%
  10. Autoimmune Disorder (a condition in which the immune system attacks the body's normal substances and tissue): 2 people, 3.17%

* Approximation only. Some reports may have incomplete information.

Do you take Vivelle-dot and have Urticaria?

- Check whether Urticaria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vivelle-dot:

Urticaria treatments and more:

How severe was Urticaria and when was it recovered:

Expand to all the drugs that have ingredients of estradiol:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vivelle-dot:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Urticaria:

Browse all the conditions that are associated with Urticaria:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Vivelle-dot) and Vivelle-dot (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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