Vivelle and Exposed bone in jaw - a phase IV clinical study of FDA data

Summary:

Exposed bone in jaw is reported as a side effect among people who take Vivelle (estradiol), especially for people who are male, 60+ old, have been taking the drug for 10+ years also take Zometa, and have Metastases to bone.

The phase IV clinical study analyzes which people have Exposed bone in jaw when taking Vivelle. It is created by eHealthMe based on reports of 6,258 people who have side effects when taking Vivelle from the FDA, and is updated regularly.

What is Vivelle?

Vivelle has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,624 Vivelle users. Check the latest studies of Vivelle.

What is Exposed bone in jaw?

Exposed bone in jaw is found to be associated with 601 drugs and 360 conditions by eHealthMe. Check the latest studies of Exposed bone in jaw.

On Aug, 12, 2026

6,258 people reported to have side effects when taking Vivelle.
Among them, 11 people (0.18%) have Exposed bone in jaw.

Could Vivelle cause Exposed bone in jaw?

Among these 11 people:

How long have people been on Vivelle when they have Exposed bone in jaw? *

What is the gender of people who have Exposed bone in jaw when taking Vivelle? *

female: 36.36 %
male: 63.64 %

What is the age of people who have Exposed bone in jaw when taking Vivelle? *

What are other drugs people take besides Vivelle? *

What are other side effects people have besides Exposed bone in jaw? *

Pain In Jaw: 11 people, 100.00%
Stress And Anxiety: 11 people, 100.00%
Pain: 11 people, 100.00%
Osteonecrosis Of Jaw (death of bone of jaw): 11 people, 100.00%
Dental Caries: 10 people, 90.91%
Toothaches (tooth pain): 10 people, 90.91%
Joint Pain: 10 people, 90.91%
Osteomyelitis (infection of bone): 9 people, 81.82%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 9 people, 81.82%
Bone Loss: 9 people, 81.82%

What are the existing conditions these people have? *

Metastases To Prostate (cancer spreads to prostate): 7 people, 63.64%
Metastases To Bone (cancer spreads to bone): 7 people, 63.64%
Osteoporosis (bones weak and more likely to break): 2 people, 18.18%
Multiple Myeloma (cancer of the plasma cells): 2 people, 18.18%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 9.09%
Stress And Anxiety: 1 person, 9.09%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 9.09%
Panic Disorder: 1 person, 9.09%
Pain: 1 person, 9.09%
Osteoporotic Fracture (fracture due to weak bone): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Vivelle and have Exposed bone in jaw?

- Check whether Exposed bone in jaw is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vivelle:

Vivelle (6,624 reports)

Browse all side effects of Vivelle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Exposed bone in jaw:

Exposed bone in jaw (601 drugs)

Browse all the conditions that are associated with Exposed bone in jaw:

Exposed bone in jaw (360 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Vivelle) and Vivelle (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.