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Vivelle and Fibula fracture - a phase IV clinical study of FDA data

Summary:

Fibula fracture is reported as a side effect among people who take Vivelle (estradiol), especially for people who are female, 50-59 old, also take Xanax, and have Bone density abnormal.

The phase IV clinical study analyzes which people have Fibula fracture when taking Vivelle. It is created by eHealthMe based on reports of 6,258 people who have side effects when taking Vivelle from the FDA, and is updated regularly.

What is Vivelle?

Vivelle has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,624 Vivelle users. Check the latest studies of Vivelle.

What is Fibula fracture?

Fibula fracture is found to be associated with 563 drugs and 580 conditions by eHealthMe. Check the latest studies of Fibula fracture.

On Jul, 16, 2026

6,258 people reported to have side effects when taking Vivelle.
Among them, 21 people (0.34%) have Fibula fracture.

Could Vivelle cause Fibula fracture?

Among these 21 people:

What is the gender of people who have Fibula fracture when taking Vivelle? *

  • female: 95.24 %
  • male: 4.76 %

What is the age of people who have Fibula fracture when taking Vivelle? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 100 %
  • 60+: 0.0 %

What are other drugs people take besides Vivelle? *

  1. Lasix: 20 people, 95.24%
  2. Synthroid: 20 people, 95.24%
  3. Xanax: 20 people, 95.24%
  4. Mucinex: 19 people, 90.48%
  5. Percocet: 19 people, 90.48%
  6. Pravachol: 18 people, 85.71%
  7. Micardis: 18 people, 85.71%
  8. Lexapro: 18 people, 85.71%
  9. Zometa: 18 people, 85.71%
  10. Klonopin: 18 people, 85.71%

What are other side effects people have besides Fibula fracture? *

  1. Fall: 21 people, 100.00%
  2. Pain: 20 people, 95.24%
  3. Foot Fracture: 19 people, 90.48%
  4. Rib Fracture: 18 people, 85.71%
  5. Retching (strong involuntary effort to vomit): 18 people, 85.71%
  6. Bronchopleural Fistula: 18 people, 85.71%
  7. Osteoradionecrosis (irradiation of bones causes damage to osteocytes and impairs the blood supply): 18 people, 85.71%
  8. Injury: 18 people, 85.71%
  9. Injury Corneal: 18 people, 85.71%
  10. Insomnia (sleeplessness): 18 people, 85.71%

What are the existing conditions these people have? *

  1. Bone Density Abnormal: 16 people, 76.19%
  2. Osteoporosis (bones weak and more likely to break): 5 people, 23.81%
  3. Primary Immunodeficiency Syndrome: 2 people, 9.52%
  4. Immunodeficiency Common Variable: 2 people, 9.52%
  5. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 4.76%
  6. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 4.76%
  7. Muscle Spasms (muscle contraction): 1 person, 4.76%
  8. Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 4.76%
  9. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Vivelle and have Fibula fracture?

- Check whether Fibula fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vivelle:

Fibula fracture treatments and more:

How severe was Fibula fracture and when was it recovered:

Expand to all the drugs that have ingredients of estradiol:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vivelle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fibula fracture:

Browse all the conditions that are associated with Fibula fracture:

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Vivelle) and Vivelle (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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