Voltaren and Application site irritation - a phase IV clinical study of FDA data

Summary:

Application site irritation is reported as a side effect among people who take Voltaren (diclofenac sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lidoderm, and have Back pain.

The phase IV clinical study analyzes which people have Application site irritation when taking Voltaren. It is created by eHealthMe based on reports of 81,356 people who have side effects when taking Voltaren from the FDA, and is updated regularly.

What is Voltaren?

Voltaren has active ingredients of diclofenac sodium. It is often used in arthritis. eHealthMe is studying from 82,346 Voltaren users. Check the latest studies of Voltaren.

What is Application site irritation?

Application site irritation is found to be associated with 390 drugs and 702 conditions by eHealthMe. Check the latest studies of Application site irritation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

81,356 people reported to have side effects when taking Voltaren.
Among them, 52 people (0.06%) have Application site irritation.

Could Voltaren cause Application site irritation?

Among these 52 people:

How long have people been on Voltaren when they have Application site irritation? *

What is the gender of people who have Application site irritation when taking Voltaren? *

female: 63.41 %
male: 36.59 %

What is the age of people who have Application site irritation when taking Voltaren? *

What are other drugs people take besides Voltaren? *

What are other side effects people have besides Application site irritation? *

Application Site Erythema (redness of the skin at application site): 20 people, 38.46%
Application Site Pain: 14 people, 26.92%
Drug Ineffective: 7 people, 13.46%
Application Site Discoloration: 7 people, 13.46%
Application Site Pruritus (application site severe itching of the skin): 5 people, 9.62%
Application Site Rash: 5 people, 9.62%
Rashes (redness): 4 people, 7.69%
Application Site Exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface): 4 people, 7.69%
Application Site Swelling: 4 people, 7.69%
Application Site Scab (hard coating on the skin formed at application site): 4 people, 7.69%

What are the existing conditions these people have? *

Back Pain: 5 people, 9.62%
Neck Pain: 4 people, 7.69%
Joint Pain: 3 people, 5.77%
Bone Pain: 3 people, 5.77%
Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 2 people, 3.85%
Muscle Aches (muscle pain): 2 people, 3.85%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 3.85%
Depression: 2 people, 3.85%
Inflammation: 2 people, 3.85%
Skin Ulcer: 2 people, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Voltaren and have Application site irritation?

- Check whether Application site irritation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Voltaren:

Voltaren (82,346 reports)

Browse all side effects of Voltaren:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site irritation:

Application site irritation (390 drugs)

Browse all the conditions that are associated with Application site irritation:

Application site irritation (702 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac sodium (the active ingredients of Voltaren) and Voltaren (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.