1. Home
  2. Analysis
  3. Vyvanse
  4. Hostility

Vyvanse and Hostility - a phase IV clinical study of FDA data

Summary:

Hostility is reported as a side effect among people who take Vyvanse (lisdexamfetamine dimesylate), especially for people who are male, 10-19 old, have been taking the drug for < 1 month also take Intuniv, and have Asperger's disorder.

The phase IV clinical study analyzes which people have Hostility when taking Vyvanse. It is created by eHealthMe based on reports of 28,083 people who have side effects when taking Vyvanse from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,862 Vyvanse users. Check the latest studies of Vyvanse.

What is Hostility?

Hostility is found to be associated with 376 drugs and 423 conditions by eHealthMe. Check the latest studies of Hostility.

On Jan, 27, 2026

28,083 people reported to have side effects when taking Vyvanse.
Among them, 38 people (0.14%) have Hostility.

Could Vyvanse cause Hostility?

Among these 38 people:

How long have people been on Vyvanse when they have Hostility? *

  • < 1 month: 36.36 %
  • 1 - 6 months: 36.36 %
  • 6 - 12 months: 18.18 %
  • 1 - 2 years: 9.09 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hostility when taking Vyvanse? *

  • female: 29.03 %
  • male: 70.97 %

What is the age of people who have Hostility when taking Vyvanse? *

  • 0-1: 0.0 %
  • 2-9: 16.67 %
  • 10-19: 45.83 %
  • 20-29: 8.33 %
  • 30-39: 8.33 %
  • 40-49: 16.67 %
  • 50-59: 0.0 %
  • 60+: 4.17 %

What are other drugs people take besides Vyvanse? *

  1. Intuniv: 3 people, 7.89%
  2. Zoloft: 2 people, 5.26%
  3. Wellbutrin: 2 people, 5.26%
  4. Concerta: 2 people, 5.26%
  5. Zyrtec: 1 person, 2.63%
  6. Klonopin: 1 person, 2.63%
  7. Cymbalta: 1 person, 2.63%
  8. Ergocalciferol: 1 person, 2.63%
  9. Eskalith: 1 person, 2.63%
  10. Focalin: 1 person, 2.63%

What are other side effects people have besides Hostility? *

  1. Aggression: 16 people, 42.11%
  2. Abnormal Behavior: 9 people, 23.68%
  3. Anger: 8 people, 21.05%
  4. Stress And Anxiety: 7 people, 18.42%
  5. Irritability: 7 people, 18.42%
  6. Mood Swings (an extreme or rapid change in mood): 5 people, 13.16%
  7. Crying: 5 people, 13.16%
  8. Suicidal Ideation: 5 people, 13.16%
  9. Fatigue (feeling of tiredness): 4 people, 10.53%
  10. Bipolar Disorder (mood disorder): 4 people, 10.53%

What are the existing conditions these people have? *

  1. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 2.63%
  2. Stress And Anxiety: 1 person, 2.63%
  3. Social Phobia (fear to go in social): 1 person, 2.63%
  4. Impulse-Control Disorder: 1 person, 2.63%
  5. Hypersensitivity: 1 person, 2.63%
  6. Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 2.63%
  7. Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 2.63%
  8. Back Pain: 1 person, 2.63%
  9. Asperger's Disorder (autism spectrum disorder that affects language and behavioural development in children): 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Vyvanse and have Hostility?

- Check whether Hostility is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vyvanse:

Hostility treatments and more:

How severe was Hostility and when was it recovered:

Expand to all the drugs that have ingredients of lisdexamfetamine dimesylate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vyvanse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hostility:

Browse all the conditions that are associated with Hostility:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lisdexamfetamine dimesylate (the active ingredients of Vyvanse) and Vyvanse (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.