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Vyvanse and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Vyvanse (lisdexamfetamine dimesylate), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Vyvanse. It is created by eHealthMe based on reports of 28,083 people who have side effects when taking Vyvanse from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,230 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Apr, 30, 2026

28,083 people reported to have side effects when taking Vyvanse.
Among them, 28 people (0.1%) have Knee joint replacement.

Could Vyvanse cause Knee joint replacement?

Among these 28 people:

How long have people been on Vyvanse when they have Knee joint replacement? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Knee joint replacement when taking Vyvanse? *

  • female: 70.37 %
  • male: 29.63 %

What is the age of people who have Knee joint replacement when taking Vyvanse? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 6.25 %
  • 40-49: 6.25 %
  • 50-59: 56.25 %
  • 60+: 31.25 %

What are other drugs people take besides Vyvanse? *

  1. Xyrem: 13 people, 46.43%
  2. Xywav: 8 people, 28.57%
  3. Vitamin D3: 8 people, 28.57%
  4. Adderall: 7 people, 25.00%
  5. Nuvigil: 7 people, 25.00%
  6. Advair Hfa: 6 people, 21.43%
  7. Omeprazole: 6 people, 21.43%
  8. Zyrtec: 5 people, 17.86%
  9. Lexapro: 5 people, 17.86%
  10. Proair Hfa: 5 people, 17.86%

What are other side effects people have besides Knee joint replacement? *

  1. Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 17.86%
  2. Bedwetting: 3 people, 10.71%
  3. Sleep-Related Eating Disorder (abnormal eating patterns during the night): 3 people, 10.71%
  4. Sleep Apnea Syndrome: 3 people, 10.71%
  5. Feeling Abnormal: 3 people, 10.71%
  6. High Blood Pressure: 3 people, 10.71%
  7. Malaise (a feeling of general discomfort or uneasiness): 3 people, 10.71%
  8. Ulcer Haemorrhage (bleeding ulcer): 2 people, 7.14%
  9. Drug Hypersensitivity: 2 people, 7.14%
  10. Pain: 2 people, 7.14%

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 64.29%
  2. Drowsiness: 12 people, 42.86%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 35.71%
  4. Pain: 2 people, 7.14%
  5. Hypergammaglobulinaemia (elevated levels of gamma globulin): 2 people, 7.14%
  6. Primary Immunodeficiency Syndrome: 1 person, 3.57%
  7. Immunodeficiency Common Variable: 1 person, 3.57%
  8. Immune System Disorder: 1 person, 3.57%
  9. High Blood Pressure: 1 person, 3.57%
  10. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Vyvanse and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vyvanse:

Knee joint replacement treatments and more:

How severe was Knee joint replacement and when was it recovered:

Expand to all the drugs that have ingredients of lisdexamfetamine dimesylate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vyvanse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Browse all the conditions that are associated with Knee joint replacement:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lisdexamfetamine dimesylate (the active ingredients of Vyvanse) and Vyvanse (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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