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Vyvanse and Paleness - a phase IV clinical study of FDA data

Summary:

Paleness is reported as a side effect among people who take Vyvanse (lisdexamfetamine dimesylate), especially for people who are male, 10-19 old, have been taking the drug for < 1 month also take Synthroid, and have High blood pressure.

The phase IV clinical study analyzes which people have Paleness when taking Vyvanse. It is created by eHealthMe based on reports of 28,083 people who have side effects when taking Vyvanse from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,870 Vyvanse users. Check the latest studies of Vyvanse.

What is Paleness?

Paleness (unusual lightness of skin colour) is found to be associated with 1,552 drugs and 2,119 conditions by eHealthMe. Check the latest studies of Paleness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

28,083 people reported to have side effects when taking Vyvanse.
Among them, 72 people (0.26%) have Paleness.

Could Vyvanse cause Paleness?

Among these 72 people:

How long have people been on Vyvanse when they have Paleness? *

  • < 1 month: 57.14 %
  • 1 - 6 months: 14.29 %
  • 6 - 12 months: 4.76 %
  • 1 - 2 years: 19.05 %
  • 2 - 5 years: 4.76 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Paleness when taking Vyvanse? *

  • female: 50 %
  • male: 50 %

What is the age of people who have Paleness when taking Vyvanse? *

  • 0-1: 0.0 %
  • 2-9: 23.08 %
  • 10-19: 28.85 %
  • 20-29: 13.46 %
  • 30-39: 5.77 %
  • 40-49: 13.46 %
  • 50-59: 15.38 %
  • 60+: 0.0 %

What are other drugs people take besides Vyvanse? *

  1. Synthroid: 15 people, 20.83%
  2. Valacyclovir: 13 people, 18.06%
  3. Tylenol: 11 people, 15.28%
  4. Benadryl: 11 people, 15.28%
  5. Amlodipine: 10 people, 13.89%
  6. Acetaminophen: 9 people, 12.50%
  7. Prednisone: 8 people, 11.11%
  8. Naproxen: 7 people, 9.72%
  9. Ativan: 7 people, 9.72%
  10. Diphenhydramine Hydrochloride: 6 people, 8.33%

What are other side effects people have besides Paleness? *

  1. Dizziness: 37 people, 51.39%
  2. Fatigue (feeling of tiredness): 35 people, 48.61%
  3. Hypotension (abnormally low blood pressure): 24 people, 33.33%
  4. Nausea (feeling of having an urge to vomit): 21 people, 29.17%
  5. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 21 people, 29.17%
  6. Pain In Extremity: 15 people, 20.83%
  7. High Blood Pressure: 14 people, 19.44%
  8. Headache (pain in head): 14 people, 19.44%
  9. Arrhythmias (irregular heartbeat): 14 people, 19.44%
  10. Blood Pressure Diastolic Abnormal: 13 people, 18.06%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 18.06%
  2. High Blood Pressure: 13 people, 18.06%
  3. Sleep Disorder: 8 people, 11.11%
  4. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 7 people, 9.72%
  5. Sle Arthritis (an autoimmune disease that causes your immune system to attack your body's own joints): 6 people, 8.33%
  6. Asthma: 4 people, 5.56%
  7. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 5.56%
  8. Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 3 people, 4.17%
  9. Migraine (headache): 3 people, 4.17%
  10. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Vyvanse and have Paleness?

- Check whether Paleness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vyvanse:

Paleness treatments and more:

How severe was Paleness and when was it recovered:

Expand to all the drugs that have ingredients of lisdexamfetamine dimesylate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vyvanse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Paleness:

Browse all the conditions that are associated with Paleness:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lisdexamfetamine dimesylate (the active ingredients of Vyvanse) and Vyvanse (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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