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Vyvanse and Poor peripheral circulation - a phase IV clinical study of FDA data

Summary:

Poor peripheral circulation is reported as a side effect among people who take Vyvanse (lisdexamfetamine dimesylate), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Valtrex, and have Narcolepsy.

The phase IV clinical study analyzes which people have Poor peripheral circulation when taking Vyvanse. It is created by eHealthMe based on reports of 28,083 people who have side effects when taking Vyvanse from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,872 Vyvanse users. Check the latest studies of Vyvanse.

What is Poor peripheral circulation?

Poor peripheral circulation is found to be associated with 532 drugs and 695 conditions by eHealthMe. Check the latest studies of Poor peripheral circulation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

28,083 people reported to have side effects when taking Vyvanse.
Among them, 18 people (0.06%) have Poor peripheral circulation.

Could Vyvanse cause Poor peripheral circulation?

Among these 18 people:

How long have people been on Vyvanse when they have Poor peripheral circulation? *

  • < 1 month: 50 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Poor peripheral circulation when taking Vyvanse? *

  • female: 62.5 %
  • male: 37.5 %

What is the age of people who have Poor peripheral circulation when taking Vyvanse? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 40 %
  • 30-39: 40 %
  • 40-49: 10 %
  • 50-59: 0.0 %
  • 60+: 10 %

What are other drugs people take besides Vyvanse? *

  1. Valtrex: 4 people, 22.22%
  2. Xyrem: 3 people, 16.67%
  3. Zonisamide: 2 people, 11.11%
  4. Diclofenac Sodium: 2 people, 11.11%
  5. Mestinon: 2 people, 11.11%
  6. Lysine: 2 people, 11.11%
  7. Hydrocortisone: 2 people, 11.11%
  8. Hydrochlorothiazide: 2 people, 11.11%
  9. Estradiol: 2 people, 11.11%
  10. Dl-Phenylalanine: 2 people, 11.11%

What are other side effects people have besides Poor peripheral circulation? *

  1. Hypoaesthesia (reduced sense of touch or sensation): 6 people, 33.33%
  2. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 5 people, 27.78%
  3. Peripheral Swelling: 3 people, 16.67%
  4. Nerve Injury: 3 people, 16.67%
  5. Weakness: 3 people, 16.67%
  6. Fatigue (feeling of tiredness): 3 people, 16.67%
  7. Dyspnea (difficult or laboured breathing): 3 people, 16.67%
  8. Blood Potassium Decreased: 3 people, 16.67%
  9. Pain In Extremity: 3 people, 16.67%
  10. Skin Discoloration: 3 people, 16.67%

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 22.22%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 16.67%
  3. Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 11.11%
  4. Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 2 people, 11.11%
  5. Drowsiness: 2 people, 11.11%
  6. Sleep Disorder: 1 person, 5.56%
  7. Multiple Myeloma (cancer of the plasma cells): 1 person, 5.56%
  8. Executive Dysfunction: 1 person, 5.56%
  9. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 1 person, 5.56%
  10. Autism Spectrum Disorder (developmental disabilities that can cause significant social, communication and behavioural challenges): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Vyvanse and have Poor peripheral circulation?

- Check whether Poor peripheral circulation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vyvanse:

Poor peripheral circulation treatments and more:

How severe was Poor peripheral circulation and when was it recovered:

Expand to all the drugs that have ingredients of lisdexamfetamine dimesylate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vyvanse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Poor peripheral circulation:

Browse all the conditions that are associated with Poor peripheral circulation:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lisdexamfetamine dimesylate (the active ingredients of Vyvanse) and Vyvanse (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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