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Vyvanse and Rotator cuff syndrome - a phase IV clinical study of FDA data

Summary:

Rotator cuff syndrome is reported as a side effect among people who take Vyvanse (lisdexamfetamine dimesylate), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Rotator cuff syndrome when taking Vyvanse. It is created by eHealthMe based on reports of 28,083 people who have side effects when taking Vyvanse from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Rotator cuff syndrome?

Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder) is found to be associated with 1,087 drugs and 1,120 conditions by eHealthMe. Check the latest studies of Rotator cuff syndrome.

On Jul, 20, 2026

28,083 people reported to have side effects when taking Vyvanse.
Among them, 18 people (0.06%) have Rotator cuff syndrome.

Could Vyvanse cause Rotator cuff syndrome?

Among these 18 people:

How long have people been on Vyvanse when they have Rotator cuff syndrome? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 50 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Rotator cuff syndrome when taking Vyvanse? *

  • female: 94.44 %
  • male: 5.56 %

What is the age of people who have Rotator cuff syndrome when taking Vyvanse? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 41.67 %
  • 50-59: 16.67 %
  • 60+: 41.67 %

What are other drugs people take besides Vyvanse? *

  1. Xyrem: 13 people, 72.22%
  2. Adderall: 7 people, 38.89%
  3. Vitamin D3: 6 people, 33.33%
  4. Synthroid: 6 people, 33.33%
  5. Fish Oil: 5 people, 27.78%
  6. Proair Hfa: 5 people, 27.78%
  7. Triamcinolone: 5 people, 27.78%
  8. Topamax: 4 people, 22.22%
  9. Advair Hfa: 4 people, 22.22%
  10. Klonopin: 4 people, 22.22%

What are other side effects people have besides Rotator cuff syndrome? *

  1. Pain: 4 people, 22.22%
  2. Drowsiness: 4 people, 22.22%
  3. Feeling Abnormal: 3 people, 16.67%
  4. Foot Deformity (functional disability of foot): 2 people, 11.11%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
  6. Hoarseness Or Changing Voice: 2 people, 11.11%
  7. Hot Flush (sudden feelings of heat): 2 people, 11.11%
  8. Dyspnea (difficult or laboured breathing): 2 people, 11.11%
  9. Panic Disorder: 2 people, 11.11%
  10. Joint Pain: 2 people, 11.11%

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 66.67%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 38.89%
  3. High Blood Pressure: 3 people, 16.67%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 16.67%
  5. Vaginal Disorder: 2 people, 11.11%
  6. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 11.11%
  7. Dizziness: 2 people, 11.11%
  8. Drug Hypersensitivity: 2 people, 11.11%
  9. Dry Eyes (lack of adequate tears): 2 people, 11.11%
  10. Dry Skin: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Vyvanse and have Rotator cuff syndrome?

- Check whether Rotator cuff syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vyvanse:

Rotator cuff syndrome treatments and more:

How severe was Rotator cuff syndrome and when was it recovered:

Expand to all the drugs that have ingredients of lisdexamfetamine dimesylate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vyvanse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Rotator cuff syndrome:

Browse all the conditions that are associated with Rotator cuff syndrome:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lisdexamfetamine dimesylate (the active ingredients of Vyvanse) and Vyvanse (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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