Wellbutrin xl and Bone disorder - a phase IV clinical study of FDA data

Summary:

Bone disorder is reported as a side effect among people who take Wellbutrin xl (bupropion hydrochloride), especially for people who are female, 50-59 old, also take Lexapro, and have Breast cancer metastatic.

The phase IV clinical study analyzes which people have Bone disorder when taking Wellbutrin xl. It is created by eHealthMe based on reports of 18,200 people who have side effects when taking Wellbutrin xl from the FDA, and is updated regularly.

What is Wellbutrin xl?

Wellbutrin xl has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 22,999 Wellbutrin xl users. Check the latest studies of Wellbutrin xl.

What is Bone disorder?

Bone disorder is found to be associated with 1,492 drugs and 1,310 conditions by eHealthMe. Check the latest studies of Bone disorder.

On Jul, 31, 2026

18,200 people reported to have side effects when taking Wellbutrin xl.
Among them, 97 people (0.53%) have Bone disorder.

Could Wellbutrin xl cause Bone disorder?

Among these 97 people:

What is the gender of people who have Bone disorder when taking Wellbutrin xl? *

female: 72.5 %
male: 27.5 %

What is the age of people who have Bone disorder when taking Wellbutrin xl? *

What are other drugs people take besides Wellbutrin xl? *

What are other side effects people have besides Bone disorder? *

Pain: 75 people, 77.32%
Back Pain: 70 people, 72.16%
Spinal Osteoarthritis (joint cartilage loss in spine): 65 people, 67.01%
Osteonecrosis Of Jaw (death of bone of jaw): 58 people, 59.79%
Intervertebral Disc Protrusion (spinal disc protrusion): 55 people, 56.70%
Metastases To Bone (cancer spreads to bone): 55 people, 56.70%
Nausea (feeling of having an urge to vomit): 51 people, 52.58%
Pain In Extremity: 49 people, 50.52%
Urinary Tract Infection: 46 people, 47.42%
Indigestion: 43 people, 44.33%

What are the existing conditions these people have? *

Breast Cancer Metastatic: 46 people, 47.42%
Breast Cancer: 23 people, 23.71%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 23 people, 23.71%
Irritable Bowel Syndrome: 22 people, 22.68%
Osteoporosis (bones weak and more likely to break): 10 people, 10.31%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 9.28%
Multiple Myeloma (cancer of the plasma cells): 7 people, 7.22%
High Blood Pressure: 6 people, 6.19%
Metastases To Bone (cancer spreads to bone): 5 people, 5.15%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 4.12%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin xl and have Bone disorder?

- Check whether Bone disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wellbutrin xl:

Wellbutrin xl (22,999 reports)

Bone disorder treatments and more:

Bone disorder (55,134 reports)

Browse all side effects of Wellbutrin xl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone disorder:

Bone disorder (1,492 drugs)

Browse all the conditions that are associated with Bone disorder:

Bone disorder (1,310 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Wellbutrin xl) and Wellbutrin xl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.