Xcopri and Restlessness aggravated - a phase IV clinical study of FDA data

Summary:

Restlessness aggravated is reported as a side effect among people who take Xcopri (cenobamate), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Keppra, and have Seizures.

The phase IV clinical study analyzes which people have Restlessness aggravated when taking Xcopri. It is created by eHealthMe based on reports of 4,132 people who have side effects when taking Xcopri from the FDA, and is updated regularly.

What is Xcopri?

Xcopri has active ingredients of cenobamate. eHealthMe is studying from 4,142 Xcopri users. Check the latest studies of Xcopri.

What is Restlessness aggravated?

Restlessness aggravated (not able to rest) is found to be associated with 1,520 drugs and 563 conditions by eHealthMe. Check the latest studies of Restlessness aggravated.

On Jul, 16, 2026

4,132 people reported to have side effects when taking Xcopri.
Among them, 52 people (1.26%) have Restlessness aggravated.

Could Xcopri cause Restlessness aggravated?

Among these 52 people:

How long have people been on Xcopri when they have Restlessness aggravated? *

What is the gender of people who have Restlessness aggravated when taking Xcopri? *

female: 20 %
male: 80 %

What is the age of people who have Restlessness aggravated when taking Xcopri? *

What are other drugs people take besides Xcopri? *

What are other side effects people have besides Restlessness aggravated? *

Fatigue (feeling of tiredness): 13 people, 25.00%
Drowsiness: 13 people, 25.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 12 people, 23.08%
Insomnia (sleeplessness): 10 people, 19.23%
Aggression: 6 people, 11.54%
Anger: 6 people, 11.54%
Mood Swings (an extreme or rapid change in mood): 6 people, 11.54%
Headache (pain in head): 5 people, 9.62%
Memory Loss: 5 people, 9.62%
Itching: 4 people, 7.69%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 31 people, 59.62%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 18 people, 34.62%
Partial Seizures (seizures which affect only a part of the brain at onset): 6 people, 11.54%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 2 people, 3.85%
Discomfort: 2 people, 3.85%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 2 people, 3.85%
Visual Field Defect: 1 person, 1.92%
Herpes Virus Infection: 1 person, 1.92%
Back Pain: 1 person, 1.92%
Bladder Spasm: 1 person, 1.92%

* Approximation only. Some reports may have incomplete information.

Do you take Xcopri and have Restlessness aggravated?

- Check whether Restlessness aggravated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xcopri:

Xcopri (4,142 reports)

Browse all side effects of Xcopri:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Restlessness aggravated:

Restlessness aggravated (1,520 drugs)

Browse all the conditions that are associated with Restlessness aggravated:

Restlessness aggravated (563 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cenobamate (the active ingredients of Xcopri) and Xcopri (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.