Xiaflex and Constipation aggravated - a phase IV clinical study of FDA data

Summary:

Constipation aggravated is reported as a side effect among people who take Xiaflex (collagenase clostridium histolyticum), especially for people who are male, 50-59 old, also take Metformin, and have Curvature of the penis.

The phase IV clinical study analyzes which people have Constipation aggravated when taking Xiaflex. It is created by eHealthMe based on reports of 5,175 people who have side effects when taking Xiaflex from the FDA, and is updated regularly.

What is Xiaflex?

Xiaflex has active ingredients of collagenase clostridium histolyticum. eHealthMe is studying from 5,177 Xiaflex users. Check the latest studies of Xiaflex.

What is Constipation aggravated?

Constipation aggravated (constipation) is found to be associated with 4,132 drugs and 4,618 conditions by eHealthMe. Check the latest studies of Constipation aggravated.

On Jun, 19, 2026

5,175 people reported to have side effects when taking Xiaflex.
Among them, 6 people (0.12%) have Constipation aggravated.

Could Xiaflex cause Constipation aggravated?

Among these 6 people:

What is the gender of people who have Constipation aggravated when taking Xiaflex? *

female: 16.67 %
male: 83.33 %

What is the age of people who have Constipation aggravated when taking Xiaflex? *

What are other drugs people take besides Xiaflex? *

Wellbutrin Xl: 1 person, 16.67%
Viagra: 1 person, 16.67%
Prilosec: 1 person, 16.67%
Metformin: 1 person, 16.67%

What are other side effects people have besides Constipation aggravated? *

Urinary Tract Infection: 1 person, 16.67%
Swelling: 1 person, 16.67%
Road Traffic Accident: 1 person, 16.67%
Rectal Tenesmus (a feeling of incomplete defecation): 1 person, 16.67%
Pain: 1 person, 16.67%
Nausea (feeling of having an urge to vomit): 1 person, 16.67%
Head Injury: 1 person, 16.67%
Fracture Of Penis (rupture of one or both of covering): 1 person, 16.67%
Drug Ineffective: 1 person, 16.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 16.67%

What are the existing conditions these people have? *

Curvature Of The Penis: 5 people, 83.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 16.67%
Dupuytren's Contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers): 1 person, 16.67%
Depression: 1 person, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Xiaflex and have Constipation aggravated?

- Check whether Constipation aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xiaflex:

Xiaflex (5,177 reports)

Constipation aggravated treatments and more:

Constipation aggravated (337,878 reports)

How severe was Constipation aggravated and when was it recovered:

Constipation aggravated in Xiaflex

Expand to all the drugs that have ingredients of collagenase clostridium histolyticum:

Constipation aggravated and drugs with ingredients of collagenase clostridium histolyticum (24 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xiaflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation aggravated:

Constipation aggravated (4,132 drugs)

Browse all the conditions that are associated with Constipation aggravated:

Constipation aggravated (4,618 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on collagenase clostridium histolyticum (the active ingredients of Xiaflex) and Xiaflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.