Xiaflex and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Xiaflex (collagenase clostridium histolyticum), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Spiriva, and have Dupuytren's contracture.

The phase IV clinical study analyzes which people have Depression when taking Xiaflex. It is created by eHealthMe based on reports of 5,175 people who have side effects when taking Xiaflex from the FDA, and is updated regularly.

What is Xiaflex?

Xiaflex has active ingredients of collagenase clostridium histolyticum. eHealthMe is studying from 5,177 Xiaflex users. Check the latest studies of Xiaflex.

What is Depression?

Depression is found to be associated with 3,204 drugs and 4,095 conditions by eHealthMe. Check the latest studies of Depression.

On Dec, 12, 2025

5,175 people reported to have side effects when taking Xiaflex.
Among them, 11 people (0.21%) have Depression.

Among these 11 people:

How long have people been on Xiaflex when they have Depression? *

What is the gender of people who have Depression when taking Xiaflex? *

female: 0.0 %
male: 100 %

What is the age of people who have Depression when taking Xiaflex? *

What are other drugs people take besides Xiaflex? *

What are other side effects people have besides Depression? *

Drug Ineffective: 6 people, 54.55%
Dyspnea (difficult or laboured breathing): 5 people, 45.45%
Heart Rate Increased: 4 people, 36.36%
Post-Traumatic Stress Disorder: 4 people, 36.36%
Memory Loss: 4 people, 36.36%
Headache (pain in head): 4 people, 36.36%
Head Injury: 4 people, 36.36%
Feeling Abnormal: 4 people, 36.36%
Eye Movement Disorder: 4 people, 36.36%
Hypotension (abnormally low blood pressure): 4 people, 36.36%

What are the existing conditions these people have? *

Dupuytren's Contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers): 7 people, 63.64%
Curvature Of The Penis: 4 people, 36.36%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 27.27%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 3 people, 27.27%
Lower Urinary Tract Symptoms: 3 people, 27.27%
Insomnia (sleeplessness): 3 people, 27.27%
Enlarged Prostate: 3 people, 27.27%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 3 people, 27.27%
Chest Pain: 3 people, 27.27%
Barrett's Oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach): 3 people, 27.27%

* Approximation only. Some reports may have incomplete information.

Do you take Xiaflex and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xiaflex:

Xiaflex (5,177 reports)

Depression treatments and more:

Depression (652,096 reports)

How severe was Depression and when was it recovered:

Depression in Xiaflex

Expand to all the drugs that have ingredients of collagenase clostridium histolyticum:

Depression and drugs with ingredients of collagenase clostridium histolyticum (24 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xiaflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,204 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,095 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on collagenase clostridium histolyticum (the active ingredients of Xiaflex) and Xiaflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.