Xiaflex and Penile pain - a phase IV clinical study of FDA data

Summary:

Penile pain is reported as a side effect among people who take Xiaflex (collagenase clostridium histolyticum), especially for people who are 50-59 old, have been taking the drug for < 1 month also take Fish Oil, and have Curvature of the penis.

The phase IV clinical study analyzes which people have Penile pain when taking Xiaflex. It is created by eHealthMe based on reports of 5,175 people who have side effects when taking Xiaflex from the FDA, and is updated regularly.

What is Xiaflex?

Xiaflex has active ingredients of collagenase clostridium histolyticum. eHealthMe is studying from 5,177 Xiaflex users. Check the latest studies of Xiaflex.

What is Penile pain?

Penile pain is found to be associated with 166 drugs and 387 conditions by eHealthMe. Check the latest studies of Penile pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

5,175 people reported to have side effects when taking Xiaflex.
Among them, 313 people (6.05%) have Penile pain.

Among these 313 people:

* Approximation only. Some reports may have incomplete information.

Do you take Xiaflex and have Penile pain?

- Check whether Penile pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xiaflex:

Xiaflex (5,177 reports)

Penile pain treatments and more:

Penile pain (3,445 reports)

How severe was Penile pain and when was it recovered:

Penile pain in Xiaflex

Expand to all the drugs that have ingredients of collagenase clostridium histolyticum:

Penile pain and drugs with ingredients of collagenase clostridium histolyticum (313 reports)

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xiaflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Penile pain:

Penile pain (166 drugs)

Browse all the conditions that are associated with Penile pain:

Penile pain (387 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on collagenase clostridium histolyticum (the active ingredients of Xiaflex) and Xiaflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.