Xifaxan and Septic shock - a phase IV clinical study of FDA data

Summary:

Septic shock is reported as a side effect among people who take Xifaxan (rifaximin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aldactone, and have Hepatic cirrhosis.

The phase IV clinical study analyzes which people have Septic shock when taking Xifaxan. It is created by eHealthMe based on reports of 16,409 people who have side effects when taking Xifaxan from the FDA, and is updated regularly.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

What is Septic shock?

Septic shock (shock due to blood infection) is found to be associated with 1,746 drugs and 3,391 conditions by eHealthMe. Check the latest studies of Septic shock.

On Jul, 05, 2026

16,409 people reported to have side effects when taking Xifaxan.
Among them, 58 people (0.35%) have Septic shock.

Among these 58 people:

How long have people been on Xifaxan when they have Septic shock? *

What is the gender of people who have Septic shock when taking Xifaxan? *

female: 64.91 %
male: 35.09 %

What is the age of people who have Septic shock when taking Xifaxan? *

What are other drugs people take besides Xifaxan? *

What are other side effects people have besides Septic shock? *

Pneumonia: 14 people, 24.14%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 10 people, 17.24%
Acute Kidney Failure: 9 people, 15.52%
Ammonia Increased: 9 people, 15.52%
Cellulitis (infection under the skin): 7 people, 12.07%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 7 people, 12.07%
Dyspnea (difficult or laboured breathing): 7 people, 12.07%
Abdominal Pain: 7 people, 12.07%
Hospitalisation: 6 people, 10.34%
Compression Fracture (fracture due to pressure caused by injury): 5 people, 8.62%

What are the existing conditions these people have? *

Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 8 people, 13.79%
High Blood Pressure: 6 people, 10.34%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 8.62%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 8.62%
Itching: 5 people, 8.62%
Oedema Peripheral (superficial swelling): 5 people, 8.62%
Portal Hypertension (increase in the blood pressure within a system of veins called the portal venous system): 5 people, 8.62%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 8.62%
Anaemia (lack of blood): 5 people, 8.62%
Nonalcoholic Fatty Liver Disease: 4 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Xifaxan and have Septic shock?

- Check whether Septic shock is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xifaxan:

Xifaxan (16,609 reports)

Septic shock treatments and more:

Septic shock (51,128 reports)

Browse all side effects of Xifaxan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Septic shock:

Septic shock (1,746 drugs)

Browse all the conditions that are associated with Septic shock:

Septic shock (3,391 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on rifaximin (the active ingredients of Xifaxan) and Xifaxan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.