Xigduo xr and Hyperkalemia - a phase IV clinical study of FDA data

Summary:

Hyperkalemia is reported as a side effect among people who take Xigduo xr (dapagliflozin propanediol; metformin hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Metformin, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Hyperkalemia when taking Xigduo xr. It is created by eHealthMe based on reports of 2,877 people who have side effects when taking Xigduo xr from the FDA, and is updated regularly.

What is Xigduo xr?

Xigduo xr has active ingredients of dapagliflozin propanediol; metformin hydrochloride. eHealthMe is studying from 2,917 Xigduo xr users. Check the latest studies of Xigduo xr.

What is Hyperkalemia?

Hyperkalemia (damage to or disease of the kidney) is found to be associated with 1,951 drugs and 2,941 conditions by eHealthMe. Check the latest studies of Hyperkalemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

2,877 people reported to have side effects when taking Xigduo xr.
Among them, 28 people (0.97%) have Hyperkalemia.

Among these 28 people:

How long have people been on Xigduo xr when they have Hyperkalemia? *

What is the gender of people who have Hyperkalemia when taking Xigduo xr? *

female: 15.38 %
male: 84.62 %

What is the age of people who have Hyperkalemia when taking Xigduo xr? *

What are other drugs people take besides Xigduo xr? *

What are other side effects people have besides Hyperkalemia? *

Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 10 people, 35.71%
Lactic Acidosis (low ph in body tissues): 6 people, 21.43%
Fatigue (feeling of tiredness): 5 people, 17.86%
Weight Decreased: 4 people, 14.29%
Overdose: 4 people, 14.29%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 14.29%
Hypoglycemia (low blood sugar): 3 people, 10.71%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 10.71%
Glucocorticoid Deficiency (less glucocorticoids secretion from kidney): 3 people, 10.71%
Depressed Mood: 3 people, 10.71%

What are the existing conditions these people have? *

Type 2 Diabetes: 12 people, 42.86%
Diabetes: 8 people, 28.57%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 3 people, 10.71%
High Blood Pressure: 2 people, 7.14%
Urticaria Pigmentosa (skin disease that produces patches of darker skin (lesions) and very bad itching): 1 person, 3.57%
Enlarged Prostate: 1 person, 3.57%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 3.57%
Cushing's Syndrome (obesity, a rounded face, increased fat): 1 person, 3.57%
Cystic Fibrosis (disease of the secretary glands): 1 person, 3.57%
Diabetic Ulcer: 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Xigduo xr and have Hyperkalemia?

- Check whether Hyperkalemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xigduo xr:

Xigduo xr (2,917 reports)

Hyperkalemia treatments and more:

Hyperkalemia (78,085 reports)

How severe was Hyperkalemia and when was it recovered:

Hyperkalemia in Xigduo xr

Expand to all the drugs that have ingredients of dapagliflozin propanediol; metformin hydrochloride:

Hyperkalemia and drugs with ingredients of dapagliflozin propanediol; metformin hydrochloride (46 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xigduo xr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkalemia:

Hyperkalemia (1,951 drugs)

Browse all the conditions that are associated with Hyperkalemia:

Hyperkalemia (2,941 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dapagliflozin propanediol; metformin hydrochloride (the active ingredients of Xigduo xr) and Xigduo xr (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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