Xigris and Pupils unequal - a phase IV clinical study of FDA data

Summary:

Pupils unequal is reported as a side effect among people who take Xigris (drotrecogin alfa (activated)), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Metronidazole, and have Sepsis.

The phase IV clinical study analyzes which people have Pupils unequal when taking Xigris. It is created by eHealthMe based on reports of 3,539 people who have side effects when taking Xigris from the FDA, and is updated regularly.

What is Xigris?

Xigris has active ingredients of drotrecogin alfa (activated). eHealthMe is studying from 3,542 Xigris users. Check the latest studies of Xigris.

What is Pupils unequal?

Pupils unequal is found to be associated with 212 drugs and 392 conditions by eHealthMe. Check the latest studies of Pupils unequal.

On Jul, 15, 2026

3,539 people reported to have side effects when taking Xigris.
Among them, 13 people (0.37%) have Pupils unequal.

Among these 13 people:

How long have people been on Xigris when they have Pupils unequal? *

What is the gender of people who have Pupils unequal when taking Xigris? *

female: 53.85 %
male: 46.15 %

What is the age of people who have Pupils unequal when taking Xigris? *

What are other drugs people take besides Xigris? *

What are other side effects people have besides Pupils unequal? *

Thrombocytopenia (decrease of platelets in blood): 6 people, 46.15%
Consciousness - Decreased: 5 people, 38.46%
Brain Death: 4 people, 30.77%
Activated Partial Thromboplastin Time Prolonged: 4 people, 30.77%
Cerebral Haemorrhage (bleeding within the brain): 3 people, 23.08%
Pupil Fixed: 3 people, 23.08%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 2 people, 15.38%
Haemorrhage Intracranial (bleeding within the skull): 2 people, 15.38%
Cerebellar Haematoma (blood collection in cerebeller): 1 person, 7.69%
Depressed Level Of Consciousness: 1 person, 7.69%

What are the existing conditions these people have? *

Septic Shock (shock due to blood infection): 5 people, 38.46%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 38.46%
Urine Output - Decreased: 1 person, 7.69%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 1 person, 7.69%
Analgesic Effect: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Xigris and have Pupils unequal?

- Check whether Pupils unequal is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xigris:

Xigris (3,542 reports)

Pupils unequal treatments and more:

Pupils unequal (1,809 reports)

Browse all side effects of Xigris:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pupils unequal:

Pupils unequal (212 drugs)

Browse all the conditions that are associated with Pupils unequal:

Pupils unequal (392 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on drotrecogin alfa (activated) (the active ingredients of Xigris) and Xigris (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.