Xofigo and Cardiac failure aggravated - a phase IV clinical study of FDA data

Summary:

Cardiac failure aggravated is reported as a side effect among people who take Xofigo (radium ra-223 dichloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Furosemide, and have Metastases to bone.

The phase IV clinical study analyzes which people have Cardiac failure aggravated when taking Xofigo. It is created by eHealthMe based on reports of 4,945 people who have side effects when taking Xofigo from the FDA, and is updated regularly.

What is Xofigo?

Xofigo has active ingredients of radium ra-223 dichloride. eHealthMe is studying from 4,948 Xofigo users. Check the latest studies of Xofigo.

What is Cardiac failure aggravated?

Cardiac failure aggravated is found to be associated with 1,819 drugs and 760 conditions by eHealthMe. Check the latest studies of Cardiac failure aggravated.

On Jul, 06, 2026

4,945 people reported to have side effects when taking Xofigo.
Among them, 26 people (0.53%) have Cardiac failure aggravated.

Could Xofigo cause Cardiac failure aggravated?

Among these 26 people:

How long have people been on Xofigo when they have Cardiac failure aggravated? *

What is the gender of people who have Cardiac failure aggravated when taking Xofigo? *

female: 4 %
male: 96 %

What is the age of people who have Cardiac failure aggravated when taking Xofigo? *

What are other drugs people take besides Xofigo? *

What are other side effects people have besides Cardiac failure aggravated? *

Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 11.54%
White Blood Cell Count Decreased: 2 people, 7.69%
Pleural Effusion (water on the lungs): 2 people, 7.69%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 2 people, 7.69%
Dyspnea (difficult or laboured breathing): 2 people, 7.69%
Metastases To Bone (cancer spreads to bone): 2 people, 7.69%
Nausea (feeling of having an urge to vomit): 2 people, 7.69%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 2 people, 7.69%
Pain: 2 people, 7.69%
Peripheral Swelling: 2 people, 7.69%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 16 people, 61.54%
Prostate Cancer: 5 people, 19.23%
Prostate Cancer Stage Iv: 4 people, 15.38%
Prostate Cancer Metastatic: 4 people, 15.38%
Enlarged Prostate: 2 people, 7.69%
Pain: 1 person, 3.85%
Metastasis (spreadable cancer to other organ from origin): 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Xofigo and have Cardiac failure aggravated?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xofigo:

Xofigo (4,948 reports)

Browse all side effects of Xofigo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cardiac failure aggravated:

Cardiac failure aggravated (1,819 drugs)

Browse all the conditions that are associated with Cardiac failure aggravated:

Cardiac failure aggravated (760 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on radium ra-223 dichloride (the active ingredients of Xofigo) and Xofigo (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.