Xpovio and Restlessness aggravated - a phase IV clinical study of FDA data

Summary:

Restlessness aggravated is reported as a side effect among people who take Xpovio (selinexor), especially for people who are have been taking the drug for < 1 month also take Zofran, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Restlessness aggravated when taking Xpovio. It is created by eHealthMe based on reports of 5,192 people who have side effects when taking Xpovio from the FDA, and is updated regularly.

What is Xpovio?

Xpovio has active ingredients of selinexor. eHealthMe is studying from 5,193 Xpovio users. Check the latest studies of Xpovio.

What is Restlessness aggravated?

Restlessness aggravated (not able to rest) is found to be associated with 1,527 drugs and 563 conditions by eHealthMe. Check the latest studies of Restlessness aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

5,192 people reported to have side effects when taking Xpovio.
Among them, 15 people (0.29%) have Restlessness aggravated.

Could Xpovio cause Restlessness aggravated?

Among these 15 people:

How long have people been on Xpovio when they have Restlessness aggravated? *

What are other drugs people take besides Xpovio? *

Zofran: 8 people, 53.33%
Dexamethasone: 5 people, 33.33%
Zyprexa: 2 people, 13.33%
Prochlorperazine: 2 people, 13.33%
Aspirin: 2 people, 13.33%
Bactrim: 2 people, 13.33%
Cyclophosphamide: 2 people, 13.33%
Gabapentin: 2 people, 13.33%
Hydrocodone Bitartrate And Acetaminophen: 2 people, 13.33%
Naloxone: 2 people, 13.33%

What are other side effects people have besides Restlessness aggravated? *

Nausea (feeling of having an urge to vomit): 12 people, 80.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 9 people, 60.00%
Fatigue (feeling of tiredness): 7 people, 46.67%
Weight Decreased: 6 people, 40.00%
Confusional State: 6 people, 40.00%
Nausea And Vomiting: 5 people, 33.33%
Diarrhea: 4 people, 26.67%
Memory Loss: 4 people, 26.67%
Multiple Myeloma (cancer of the plasma cells): 4 people, 26.67%
Weakness: 4 people, 26.67%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 93.33%
Nausea (feeling of having an urge to vomit): 3 people, 20.00%
Pain: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Xpovio and have Restlessness aggravated?

- Check whether Restlessness aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xpovio:

Xpovio (5,193 reports)

Browse all side effects of Xpovio:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Restlessness aggravated:

Restlessness aggravated (1,527 drugs)

Browse all the conditions that are associated with Restlessness aggravated:

Restlessness aggravated (563 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on selinexor (the active ingredients of Xpovio) and Xpovio (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.