Xylocaine and Hyperkalemia - a phase IV clinical study of FDA data

Summary:

Hyperkalemia is reported as a side effect among people who take Xylocaine (lidocaine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Hyperkalemia when taking Xylocaine. It is created by eHealthMe based on reports of 5,700 people who have side effects when taking Xylocaine from the FDA, and is updated regularly.

What is Xylocaine?

Xylocaine has active ingredients of lidocaine hydrochloride. eHealthMe is studying from 5,716 Xylocaine users. Check the latest studies of Xylocaine.

What is Hyperkalemia?

Hyperkalemia (damage to or disease of the kidney) is found to be associated with 1,951 drugs and 2,941 conditions by eHealthMe. Check the latest studies of Hyperkalemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

5,700 people reported to have side effects when taking Xylocaine.
Among them, 51 people (0.89%) have Hyperkalemia.

Among these 51 people:

How long have people been on Xylocaine when they have Hyperkalemia? *

What is the gender of people who have Hyperkalemia when taking Xylocaine? *

female: 20.83 %
male: 79.17 %

What is the age of people who have Hyperkalemia when taking Xylocaine? *

What are other drugs people take besides Xylocaine? *

What are other side effects people have besides Hyperkalemia? *

Blood Urea Increased: 17 people, 33.33%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 16 people, 31.37%
Blood Lactate Dehydrogenase Increased: 15 people, 29.41%
Haemoglobin Decreased: 14 people, 27.45%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 14 people, 27.45%
Pleural Effusion (water on the lungs): 14 people, 27.45%
Febrile Neutropenia (fever with reduced white blood cells): 13 people, 25.49%
Blood Uric Acid Increased: 13 people, 25.49%
Blood Alkaline Phosphatase Decreased: 13 people, 25.49%
Protein Total Increased: 12 people, 23.53%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 12 people, 23.53%
Cardiac Failure: 8 people, 15.69%
Convulsion Neonatal (muscle contraction and relaxation rapidly in neonate): 4 people, 7.84%
Gastric Cancer (stomach cancer): 3 people, 5.88%
Rash Maculo-Papular (red area on the skin that is covered with small confluent bumps): 3 people, 5.88%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 5.88%
Anaesthesia: 2 people, 3.92%
Cardiac Failure Congestive: 2 people, 3.92%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 3.92%
Hypotension (abnormally low blood pressure): 2 people, 3.92%

* Approximation only. Some reports may have incomplete information.

Do you take Xylocaine and have Hyperkalemia?

- Check whether Hyperkalemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xylocaine:

Xylocaine (5,716 reports)

Hyperkalemia treatments and more:

Hyperkalemia (78,085 reports)

Browse all side effects of Xylocaine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkalemia:

Hyperkalemia (1,951 drugs)

Browse all the conditions that are associated with Hyperkalemia:

Hyperkalemia (2,941 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lidocaine hydrochloride (the active ingredients of Xylocaine) and Xylocaine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.