Xylocaine and Intervertebral disc protrusion - a phase IV clinical study of FDA data

Summary:

Intervertebral disc protrusion is reported as a side effect among people who take Xylocaine (lidocaine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Zometa, and have Metastases to bone.

The phase IV clinical study analyzes which people have Intervertebral disc protrusion when taking Xylocaine. It is created by eHealthMe based on reports of 5,700 people who have side effects when taking Xylocaine from the FDA, and is updated regularly.

What is Xylocaine?

Xylocaine has active ingredients of lidocaine hydrochloride. eHealthMe is studying from 5,716 Xylocaine users. Check the latest studies of Xylocaine.

What is Intervertebral disc protrusion?

Intervertebral disc protrusion (spinal disc protrusion) is found to be associated with 1,531 drugs and 1,305 conditions by eHealthMe. Check the latest studies of Intervertebral disc protrusion.

On Jul, 16, 2026

5,700 people reported to have side effects when taking Xylocaine.
Among them, 36 people (0.63%) have Intervertebral disc protrusion.

Could Xylocaine cause Intervertebral disc protrusion?

Among these 36 people:

How long have people been on Xylocaine when they have Intervertebral disc protrusion? *

What is the gender of people who have Intervertebral disc protrusion when taking Xylocaine? *

female: 55.56 %
male: 44.44 %

What is the age of people who have Intervertebral disc protrusion when taking Xylocaine? *

What are other drugs people take besides Xylocaine? *

What are other side effects people have besides Intervertebral disc protrusion? *

Joint Pain: 29 people, 80.56%
Pain: 29 people, 80.56%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 26 people, 72.22%
Neuropathy Peripheral (surface nerve damage): 25 people, 69.44%
Metastases To Spine (cancer spreads to spine): 25 people, 69.44%
Fall: 24 people, 66.67%
Back Pain: 23 people, 63.89%
Constipation: 23 people, 63.89%
General Physical Health Deterioration (weak health status): 23 people, 63.89%
Stress And Anxiety: 23 people, 63.89%

What are the existing conditions these people have? *

Prostate Cancer: 8 people, 22.22%
Metastases To Bone (cancer spreads to bone): 8 people, 22.22%
Pain: 4 people, 11.11%
Multiple Myeloma (cancer of the plasma cells): 4 people, 11.11%
Seasonal Allergy (allergic condition due to certain season): 4 people, 11.11%
High Blood Cholesterol: 4 people, 11.11%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 8.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 5.56%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 2 people, 5.56%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Xylocaine and have Intervertebral disc protrusion?

- Check whether Intervertebral disc protrusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xylocaine:

Xylocaine (5,716 reports)

Browse all side effects of Xylocaine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc protrusion:

Intervertebral disc protrusion (1,531 drugs)

Browse all the conditions that are associated with Intervertebral disc protrusion:

Intervertebral disc protrusion (1,305 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lidocaine hydrochloride (the active ingredients of Xylocaine) and Xylocaine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.