Yaz and Multiple sclerosis relapse - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis relapse is reported as a side effect among people who take Yaz (drospirenone; ethinyl estradiol), especially for people who are female, 40-49 old, have been taking the drug for 6 - 12 months also take Tysabri, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Multiple sclerosis relapse when taking Yaz. It is created by eHealthMe based on reports of 39,984 people who have side effects when taking Yaz from the FDA, and is updated regularly.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

What is Multiple sclerosis relapse?

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,029 drugs and 943 conditions by eHealthMe. Check the latest studies of Multiple sclerosis relapse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

39,984 people reported to have side effects when taking Yaz.
Among them, 37 people (0.09%) have Multiple sclerosis relapse.

Could Yaz cause Multiple sclerosis relapse?

Among these 37 people:

How long have people been on Yaz when they have Multiple sclerosis relapse? *

What is the gender of people who have Multiple sclerosis relapse when taking Yaz? *

female: 91.89 %
male: 8.11 %

What is the age of people who have Multiple sclerosis relapse when taking Yaz? *

What are other drugs people take besides Yaz? *

What are other side effects people have besides Multiple sclerosis relapse? *

Pain: 15 people, 40.54%
Injury: 13 people, 35.14%
Weakness: 9 people, 24.32%
Headache (pain in head): 8 people, 21.62%
Urinary Tract Infection: 8 people, 21.62%
Pulmonary Embolism (blockage of the main artery of the lung): 8 people, 21.62%
Gait Disturbance: 7 people, 18.92%
Depression: 7 people, 18.92%
Stress And Anxiety: 6 people, 16.22%
Fatigue (feeling of tiredness): 6 people, 16.22%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 30 people, 81.08%
Premenstrual Syndrome: 9 people, 24.32%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 13.51%
Depression: 5 people, 13.51%
Thyroid Diseases: 3 people, 8.11%
Stress And Anxiety: 3 people, 8.11%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 3 people, 8.11%
Pain: 3 people, 8.11%
Migraine (headache): 3 people, 8.11%
Menstruation Irregular: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Yaz and have Multiple sclerosis relapse?

- Check whether Multiple sclerosis relapse is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Yaz:

Yaz (41,514 reports)

Multiple sclerosis relapse treatments and more:

Multiple sclerosis relapse (89,124 reports)

How severe was Multiple sclerosis relapse and when was it recovered:

Multiple sclerosis relapse in Yaz

Expand to all the drugs that have ingredients of drospirenone; ethinyl estradiol:

Multiple sclerosis relapse and drugs with ingredients of drospirenone; ethinyl estradiol (84 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Yaz:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis relapse:

Multiple sclerosis relapse (1,029 drugs)

Browse all the conditions that are associated with Multiple sclerosis relapse:

Multiple sclerosis relapse (943 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on drospirenone; ethinyl estradiol (the active ingredients of Yaz) and Yaz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.