Zaltrap and Nosebleed - a phase IV clinical study of FDA data

Summary:

Nosebleed is reported as a side effect among people who take Zaltrap (ziv-aflibercept), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Ondansetron, and have Colorectal cancer metastatic.

The phase IV clinical study analyzes which people have Nosebleed when taking Zaltrap. It is created by eHealthMe based on reports of 1,432 people who have side effects when taking Zaltrap from the FDA, and is updated regularly.

What is Zaltrap?

Zaltrap has active ingredients of ziv-aflibercept. eHealthMe is studying from 1,432 Zaltrap users. Check the latest studies of Zaltrap.

What is Nosebleed?

Nosebleed (bleeding from nose) is found to be associated with 2,074 drugs and 3,094 conditions by eHealthMe. Check the latest studies of Nosebleed.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

1,432 people reported to have side effects when taking Zaltrap.
Among them, 36 people (2.51%) have Nosebleed.

Among these 36 people:

How long have people been on Zaltrap when they have Nosebleed? *

What is the gender of people who have Nosebleed when taking Zaltrap? *

female: 50 %
male: 50 %

What is the age of people who have Nosebleed when taking Zaltrap? *

What are other drugs people take besides Zaltrap? *

Ondansetron: 5 people, 13.89%
Fluorouracil: 4 people, 11.11%
Topamax: 3 people, 8.33%
Movicol: 3 people, 8.33%
Ranitidine: 2 people, 5.56%
Lorazepam: 2 people, 5.56%
Irinotecan Hydrochloride: 2 people, 5.56%
Hydrocodone: 2 people, 5.56%
Emend: 2 people, 5.56%
Aloxi: 2 people, 5.56%

What are other side effects people have besides Nosebleed? *

High Blood Pressure: 15 people, 41.67%
Diarrhea: 11 people, 30.56%
Hoarseness Or Changing Voice: 11 people, 30.56%
Fever: 8 people, 22.22%
Herpes Ophthalmic (eye infection caused by herpes simplex virus (hsv)): 8 people, 22.22%
Rectal Haemorrhage (bleeding from anus): 8 people, 22.22%
Back Pain: 7 people, 19.44%
Constipation: 7 people, 19.44%
Headache (pain in head): 5 people, 13.89%
Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 11.11%

What are the existing conditions these people have? *

Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 18 people, 50.00%
Colon Cancer: 5 people, 13.89%
Rectal Cancer (cancer of rectum): 4 people, 11.11%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 3 people, 8.33%
Dyslipidaemia (abnormal amount of lipids): 3 people, 8.33%
Rectosigmoid Cancer Recurrent (reoccurrence of cancer that originates in the rectum and sigmoid colon): 2 people, 5.56%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 2.78%
Rectal Cancer Recurrent (reoccurrence of rectum cancer): 1 person, 2.78%
Nausea And Vomiting: 1 person, 2.78%
High Blood Pressure: 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Zaltrap and have Nosebleed?

- Check whether Nosebleed is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zaltrap:

Zaltrap (1,432 reports)

Nosebleed treatments and more:

Nosebleed (92,075 reports)

Browse all side effects of Zaltrap:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nosebleed:

Nosebleed (2,074 drugs)

Browse all the conditions that are associated with Nosebleed:

Nosebleed (3,094 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ziv-aflibercept (the active ingredients of Zaltrap) and Zaltrap (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.