Zaroxolyn and Sleep disorder - a phase IV clinical study of FDA data

Summary:

Sleep disorder is reported as a side effect among people who take Zaroxolyn (metolazone), especially for people who are female, 60+ old, also take Lasix, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Sleep disorder when taking Zaroxolyn. It is created by eHealthMe based on reports of 5,225 people who have side effects when taking Zaroxolyn from the FDA, and is updated regularly.

What is Zaroxolyn?

Zaroxolyn has active ingredients of metolazone. It is often used in high blood pressure. eHealthMe is studying from 5,244 Zaroxolyn users. Check the latest studies of Zaroxolyn.

What is Sleep disorder?

Sleep disorder is found to be associated with 2,108 drugs and 2,932 conditions by eHealthMe. Check the latest studies of Sleep disorder.

On Apr, 25, 2026

5,225 people reported to have side effects when taking Zaroxolyn.
Among them, 28 people (0.54%) have Sleep disorder.

Among these 28 people:

What is the gender of people who have Sleep disorder when taking Zaroxolyn? *

female: 53.85 %
male: 46.15 %

What is the age of people who have Sleep disorder when taking Zaroxolyn? *

What are other drugs people take besides Zaroxolyn? *

What are other side effects people have besides Sleep disorder? *

Dyspnea (difficult or laboured breathing): 12 people, 42.86%
Chest Pain: 12 people, 42.86%
Fatigue (feeling of tiredness): 11 people, 39.29%
Weight Increased: 10 people, 35.71%
Oedema Peripheral (superficial swelling): 9 people, 32.14%
Weakness: 9 people, 32.14%
Nausea (feeling of having an urge to vomit): 9 people, 32.14%
Stress And Anxiety: 9 people, 32.14%
Constipation: 9 people, 32.14%
Pain: 8 people, 28.57%

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 10.71%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 10.71%
Upper-Airway Cough Syndrome: 2 people, 7.14%
Pain: 2 people, 7.14%
Blood Pressure Abnormal: 2 people, 7.14%
Cough: 2 people, 7.14%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 7.14%
Multiple Myeloma (cancer of the plasma cells): 2 people, 7.14%
Oedema Peripheral (superficial swelling): 2 people, 7.14%
Asthma: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Zaroxolyn and have Sleep disorder?

- Check whether Sleep disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zaroxolyn:

Zaroxolyn (5,244 reports)

Sleep disorder treatments and more:

Sleep disorder (167,335 reports)

Browse all side effects of Zaroxolyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sleep disorder:

Sleep disorder (2,108 drugs)

Browse all the conditions that are associated with Sleep disorder:

Sleep disorder (2,932 conditions)

Related publications that referenced our studies

Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on metolazone (the active ingredients of Zaroxolyn) and Zaroxolyn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.