Zaroxolyn and Urine output - decreased - a phase IV clinical study of FDA data

Summary:

Urine output - decreased is reported as a side effect among people who take Zaroxolyn (metolazone), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Pulmonary hypertension.

The phase IV clinical study analyzes which people have Urine output - decreased when taking Zaroxolyn. It is created by eHealthMe based on reports of 5,225 people who have side effects when taking Zaroxolyn from the FDA, and is updated regularly.

What is Zaroxolyn?

Zaroxolyn has active ingredients of metolazone. It is often used in high blood pressure. eHealthMe is studying from 5,244 Zaroxolyn users. Check the latest studies of Zaroxolyn.

What is Urine output - decreased?

Urine output - decreased is found to be associated with 1,277 drugs and 1,292 conditions by eHealthMe. Check the latest studies of Urine output - decreased.

On Jul, 17, 2026

5,225 people reported to have side effects when taking Zaroxolyn.
Among them, 34 people (0.65%) have Urine output - decreased.

Could Zaroxolyn cause Urine output - decreased?

Among these 34 people:

How long have people been on Zaroxolyn when they have Urine output - decreased? *

What is the gender of people who have Urine output - decreased when taking Zaroxolyn? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Urine output - decreased when taking Zaroxolyn? *

What are other drugs people take besides Zaroxolyn? *

What are other side effects people have besides Urine output - decreased? *

Hypotension (abnormally low blood pressure): 15 people, 44.12%
Blood Creatinine Increased: 12 people, 35.29%
Blood Urea Increased: 11 people, 32.35%
Acute Kidney Failure: 11 people, 32.35%
Fluid Retention (an abnormal accumulation of fluid in the blood): 11 people, 32.35%
Weakness: 10 people, 29.41%
Haemoglobin Decreased: 9 people, 26.47%
Weight Increased: 9 people, 26.47%
Hyperkalemia (damage to or disease of the kidney): 9 people, 26.47%
Mitral Valve Incompetence (inefficient heart valve): 9 people, 26.47%

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 6 people, 17.65%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 14.71%
Pulmonary Hypertension Primary (increase in blood pressure in the lung artery with no cause): 1 person, 2.94%
Multiple Myeloma (cancer of the plasma cells): 1 person, 2.94%
Depression: 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Zaroxolyn and have Urine output - decreased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zaroxolyn:

Zaroxolyn (5,244 reports)

Browse all side effects of Zaroxolyn:

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Browse all the drugs that are associated with Urine output - decreased:

Urine output - decreased (1,277 drugs)

Browse all the conditions that are associated with Urine output - decreased:

Urine output - decreased (1,292 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metolazone (the active ingredients of Zaroxolyn) and Zaroxolyn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.