Zeaxanthin and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Zeaxanthin (lutein), especially for people who are female, 60+ old, also take Vitamin D3, and have Crohn's disease.

The phase IV clinical study analyzes which people have Headache when taking Zeaxanthin. It is created by eHealthMe based on reports of 1,621 people who have side effects when taking Zeaxanthin from the FDA, and is updated regularly.

What is Zeaxanthin?

Zeaxanthin has active ingredients of lutein. It is often used in macular degeneration. eHealthMe is studying from 1,687 Zeaxanthin users. Check the latest studies of Zeaxanthin.

What is Headache?

Headache (pain in head) is found to be associated with 3,746 drugs and 5,761 conditions by eHealthMe. Check the latest studies of Headache.

On May, 20, 2026

1,621 people reported to have side effects when taking Zeaxanthin.
Among them, 225 people (13.88%) have Headache.

Among these 225 people:

* Approximation only. Some reports may have incomplete information.

Do you take Zeaxanthin and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zeaxanthin:

Zeaxanthin (1,687 reports)

Headache treatments and more:

Headache (756,640 reports)

How severe was Headache and when was it recovered:

Headache in Zeaxanthin

Expand to all the drugs that have ingredients of lutein:

Headache and drugs with ingredients of lutein (557 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zeaxanthin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,746 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,761 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lutein (the active ingredients of Zeaxanthin) and Zeaxanthin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.