Zemplar and Aortic stenosis - a phase IV clinical study of FDA data

Summary:

Aortic stenosis is reported as a side effect among people who take Zemplar (paricalcitol), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Aspirin, and have Hyperparathyroidism secondary.

The phase IV clinical study analyzes which people have Aortic stenosis when taking Zemplar. It is created by eHealthMe based on reports of 15,456 people who have side effects when taking Zemplar from the FDA, and is updated regularly.

What is Zemplar?

Zemplar has active ingredients of paricalcitol. It is often used in kidney disease. eHealthMe is studying from 15,494 Zemplar users. Check the latest studies of Zemplar.

What is Aortic stenosis?

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta) is found to be associated with 779 drugs and 972 conditions by eHealthMe. Check the latest studies of Aortic stenosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

15,456 people reported to have side effects when taking Zemplar.
Among them, 30 people (0.19%) have Aortic stenosis.

Among these 30 people:

How long have people been on Zemplar when they have Aortic stenosis? *

What is the gender of people who have Aortic stenosis when taking Zemplar? *

female: 35.71 %
male: 64.29 %

What is the age of people who have Aortic stenosis when taking Zemplar? *

What are other drugs people take besides Zemplar? *

What are other side effects people have besides Aortic stenosis? *

Coronary Heart Disease (narrowing or blockage of the coronary arteries): 8 people, 26.67%
Cardiac Failure: 8 people, 26.67%
Chronic Renal Failure (kidney failure): 7 people, 23.33%
Hypotension (abnormally low blood pressure): 6 people, 20.00%
Anaemia (lack of blood): 6 people, 20.00%
Dyspnea (difficult or laboured breathing): 5 people, 16.67%
High Blood Pressure: 5 people, 16.67%
Cardiac Arrest: 5 people, 16.67%
Nausea (feeling of having an urge to vomit): 5 people, 16.67%
Pneumonia: 5 people, 16.67%

What are the existing conditions these people have? *

Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 16 people, 53.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 16.67%
High Blood Cholesterol: 5 people, 16.67%
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium): 4 people, 13.33%
Blockage Of Leg Arteries: 3 people, 10.00%
Peripheral Neuropathy (damage to nerves of the peripheral nervous system): 3 people, 10.00%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 3 people, 10.00%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 10.00%
Diabetes: 3 people, 10.00%
Enlarged Prostate: 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zemplar and have Aortic stenosis?

- Check whether Aortic stenosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zemplar:

Zemplar (15,494 reports)

Aortic stenosis treatments and more:

Aortic stenosis (8,138 reports)

Browse all side effects of Zemplar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic stenosis:

Aortic stenosis (779 drugs)

Browse all the conditions that are associated with Aortic stenosis:

Aortic stenosis (972 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on paricalcitol (the active ingredients of Zemplar) and Zemplar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.