Zepatier and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Zepatier (elbasvir; grazoprevir), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Rebetol, and have Hepatitis c.

The phase IV clinical study analyzes which people have Depression when taking Zepatier. It is created by eHealthMe based on reports of 4,481 people who have side effects when taking Zepatier from the FDA, and is updated regularly.

What is Zepatier?

Zepatier has active ingredients of elbasvir; grazoprevir. eHealthMe is studying from 4,482 Zepatier users. Check the latest studies of Zepatier.

What is Depression?

Depression is found to be associated with 3,167 drugs and 4,125 conditions by eHealthMe. Check the latest studies of Depression.

On Jul, 20, 2026

4,481 people reported to have side effects when taking Zepatier.
Among them, 75 people (1.67%) have Depression.

Among these 75 people:

How long have people been on Zepatier when they have Depression? *

What is the gender of people who have Depression when taking Zepatier? *

female: 45.07 %
male: 54.93 %

What is the age of people who have Depression when taking Zepatier? *

What are other drugs people take besides Zepatier? *

What are other side effects people have besides Depression? *

Fatigue (feeling of tiredness): 19 people, 25.33%
Stress And Anxiety: 13 people, 17.33%
Insomnia (sleeplessness): 13 people, 17.33%
Nausea (feeling of having an urge to vomit): 12 people, 16.00%
Headache (pain in head): 10 people, 13.33%
Suicidal Ideation: 10 people, 13.33%
Pain: 9 people, 12.00%
Weight Decreased: 8 people, 10.67%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 7 people, 9.33%
Diarrhea: 6 people, 8.00%

What are the existing conditions these people have? *

Hepatitis C: 39 people, 52.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 1.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 1.33%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 1.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 1.33%
Hepatitis B: 1 person, 1.33%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 1 person, 1.33%
Diabetes: 1 person, 1.33%
Cryoglobulinaemia (blood contains large amounts of cryoglobulins - proteins): 1 person, 1.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 1.33%

* Approximation only. Some reports may have incomplete information.

Do you take Zepatier and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zepatier:

Zepatier (4,482 reports)

Depression treatments and more:

Depression (652,144 reports)

Browse all side effects of Zepatier:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,167 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,125 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on elbasvir; grazoprevir (the active ingredients of Zepatier) and Zepatier (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.