Zestoretic and Fluid overload - a phase IV clinical study of FDA data

Summary:

Fluid overload is reported as a side effect among people who take Zestoretic (hydrochlorothiazide; lisinopril), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Synthroid, and have Dehydration.

The phase IV clinical study analyzes which people have Fluid overload when taking Zestoretic. It is created by eHealthMe based on reports of 4,193 people who have side effects when taking Zestoretic from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Fluid overload?

Fluid overload (too much fluid in the blood) is found to be associated with 1,030 drugs and 1,050 conditions by eHealthMe. Check the latest studies of Fluid overload.

On Jul, 11, 2026

4,193 people reported to have side effects when taking Zestoretic.
Among them, 13 people (0.31%) have Fluid overload.

Among these 13 people:

How long have people been on Zestoretic when they have Fluid overload? *

What is the gender of people who have Fluid overload when taking Zestoretic? *

female: 61.54 %
male: 38.46 %

What is the age of people who have Fluid overload when taking Zestoretic? *

What are other drugs people take besides Zestoretic? *

What are other side effects people have besides Fluid overload? *

Cardiac Failure Congestive: 7 people, 53.85%
Abdominal Distension: 6 people, 46.15%
Hyperkalemia (damage to or disease of the kidney): 6 people, 46.15%
Acute Kidney Failure: 5 people, 38.46%
Anaemia (lack of blood): 5 people, 38.46%
Arrhythmias (irregular heartbeat): 5 people, 38.46%
Dyspnea (difficult or laboured breathing): 5 people, 38.46%
Dehydration (dryness resulting from the removal of water): 4 people, 30.77%
Rashes (redness): 4 people, 30.77%
Fatigue (feeling of tiredness): 4 people, 30.77%

What are the existing conditions these people have? *

Sleep Disorder: 3 people, 23.08%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 23.08%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 23.08%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 3 people, 23.08%
Pain: 3 people, 23.08%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 23.08%
Hypotension (abnormally low blood pressure): 3 people, 23.08%
Dehydration (dryness resulting from the removal of water): 3 people, 23.08%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 15.38%
Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Zestoretic and have Fluid overload?

- Check whether Fluid overload is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestoretic:

Zestoretic (4,342 reports)

Fluid overload treatments and more:

Fluid overload (20,385 reports)

How severe was Fluid overload and when was it recovered:

Fluid overload in Zestoretic

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Fluid overload and drugs with ingredients of hydrochlorothiazide; lisinopril

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zestoretic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid overload:

Fluid overload (1,030 drugs)

Browse all the conditions that are associated with Fluid overload:

Fluid overload (1,050 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Zestoretic) and Zestoretic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.