Zestoretic and Gastrointestinal disorder - a phase IV clinical study of FDA data

Summary:

Gastrointestinal disorder is reported as a side effect among people who take Zestoretic (hydrochlorothiazide; lisinopril), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Celebrex, and have Metabolic syndrome.

The phase IV clinical study analyzes which people have Gastrointestinal disorder when taking Zestoretic. It is created by eHealthMe based on reports of 4,193 people who have side effects when taking Zestoretic from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Gastrointestinal disorder?

Gastrointestinal disorder (functional problems of gastrointestinal tract) is found to be associated with 2,091 drugs and 1,907 conditions by eHealthMe. Check the latest studies of Gastrointestinal disorder.

On Jul, 09, 2026

4,193 people reported to have side effects when taking Zestoretic.
Among them, 19 people (0.45%) have Gastrointestinal disorder.

Could Zestoretic cause Gastrointestinal disorder?

Among these 19 people:

How long have people been on Zestoretic when they have Gastrointestinal disorder? *

What is the gender of people who have Gastrointestinal disorder when taking Zestoretic? *

female: 63.16 %
male: 36.84 %

What is the age of people who have Gastrointestinal disorder when taking Zestoretic? *

What are other drugs people take besides Zestoretic? *

What are other side effects people have besides Gastrointestinal disorder? *

Dizziness: 7 people, 36.84%
Joint Pain: 7 people, 36.84%
Muscle Aches (muscle pain): 7 people, 36.84%
Weakness: 6 people, 31.58%
Balance Disorder: 6 people, 31.58%
Muscle Rigidity (muscle stiffness): 6 people, 31.58%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 6 people, 31.58%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 5 people, 26.32%
Anaemia (lack of blood): 5 people, 26.32%
Purpura (purplish discoloration of the skin): 5 people, 26.32%

What are the existing conditions these people have? *

Metabolic Syndrome (a combination of the medical disorders that, when occurring together, increase the risk of developing cardiovascular disease): 5 people, 26.32%
Depression: 2 people, 10.53%
Weight Loss: 1 person, 5.26%
Stress And Anxiety: 1 person, 5.26%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 1 person, 5.26%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.26%
Pain: 1 person, 5.26%
Muscle Spasms (muscle contraction): 1 person, 5.26%
Ill-Defined Disorder: 1 person, 5.26%
Hepatic Neoplasm Malignant (liver cancer): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Zestoretic and have Gastrointestinal disorder?

- Check whether Gastrointestinal disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestoretic:

Zestoretic (4,342 reports)

Gastrointestinal disorder treatments and more:

Gastrointestinal disorder (110,021 reports)

How severe was Gastrointestinal disorder and when was it recovered:

Gastrointestinal disorder in Zestoretic

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Gastrointestinal disorder and drugs with ingredients of hydrochlorothiazide; lisinopril

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zestoretic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastrointestinal disorder:

Gastrointestinal disorder (2,091 drugs)

Browse all the conditions that are associated with Gastrointestinal disorder:

Gastrointestinal disorder (1,907 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Zestoretic) and Zestoretic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.