Zestoretic and Intervertebral disc degeneration - a phase IV clinical study of FDA data

Summary:

Intervertebral disc degeneration is reported as a side effect among people who take Zestoretic (hydrochlorothiazide; lisinopril), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Vioxx, and have Muscle spasms.

The phase IV clinical study analyzes which people have Intervertebral disc degeneration when taking Zestoretic. It is created by eHealthMe based on reports of 4,193 people who have side effects when taking Zestoretic from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Intervertebral disc degeneration?

Intervertebral disc degeneration (spinal disc degeneration) is found to be associated with 1,316 drugs and 1,496 conditions by eHealthMe. Check the latest studies of Intervertebral disc degeneration.

On Jul, 13, 2026

4,193 people reported to have side effects when taking Zestoretic.
Among them, 26 people (0.62%) have Intervertebral disc degeneration.

Could Zestoretic cause Intervertebral disc degeneration?

Among these 26 people:

How long have people been on Zestoretic when they have Intervertebral disc degeneration? *

What is the gender of people who have Intervertebral disc degeneration when taking Zestoretic? *

female: 57.69 %
male: 42.31 %

What is the age of people who have Intervertebral disc degeneration when taking Zestoretic? *

What are other drugs people take besides Zestoretic? *

What are other side effects people have besides Intervertebral disc degeneration? *

Chest Pain: 16 people, 61.54%
Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 16 people, 61.54%
Intervertebral Disc Protrusion (spinal disc protrusion): 14 people, 53.85%
Depression: 13 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 50.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 13 people, 50.00%
Anaemia (lack of blood): 13 people, 50.00%
Weight Increased: 13 people, 50.00%
Constipation: 12 people, 46.15%
Acute Kidney Failure: 12 people, 46.15%

What are the existing conditions these people have? *

Muscle Spasms (muscle contraction): 12 people, 46.15%
Back Pain: 10 people, 38.46%
Type 2 Diabetes: 3 people, 11.54%
Asthma: 3 people, 11.54%
Pain: 2 people, 7.69%
Neck Pain: 2 people, 7.69%
Nausea (feeling of having an urge to vomit): 2 people, 7.69%
Multiple Myeloma (cancer of the plasma cells): 2 people, 7.69%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 7.69%
Joint Swelling: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Zestoretic and have Intervertebral disc degeneration?

- Check whether Intervertebral disc degeneration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestoretic:

Zestoretic (4,342 reports)

Intervertebral disc degeneration treatments and more:

Intervertebral disc degeneration (19,910 reports)

How severe was Intervertebral disc degeneration and when was it recovered:

Intervertebral disc degeneration in Zestoretic

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Intervertebral disc degeneration and drugs with ingredients of hydrochlorothiazide; lisinopril (79 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zestoretic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,316 drugs)

Browse all the conditions that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,496 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Zestoretic) and Zestoretic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.