Zestoretic and Musculoskeletal stiffness - a phase IV clinical study of FDA data

Summary:

Musculoskeletal stiffness is reported as a side effect among people who take Zestoretic (hydrochlorothiazide; lisinopril), especially for people who are female, 60+ old, also take Neurontin, and have Pain.

The phase IV clinical study analyzes which people have Musculoskeletal stiffness when taking Zestoretic. It is created by eHealthMe based on reports of 4,193 people who have side effects when taking Zestoretic from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Musculoskeletal stiffness?

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves) is found to be associated with 1,959 drugs and 1,917 conditions by eHealthMe. Check the latest studies of Musculoskeletal stiffness.

On Jul, 07, 2026

4,193 people reported to have side effects when taking Zestoretic.
Among them, 13 people (0.31%) have Musculoskeletal stiffness.

Could Zestoretic cause Musculoskeletal stiffness?

Among these 13 people:

What is the gender of people who have Musculoskeletal stiffness when taking Zestoretic? *

female: 76.92 %
male: 23.08 %

What is the age of people who have Musculoskeletal stiffness when taking Zestoretic? *

What are other drugs people take besides Zestoretic? *

What are other side effects people have besides Musculoskeletal stiffness? *

Joint Pain: 6 people, 46.15%
Weakness: 5 people, 38.46%
Depression: 5 people, 38.46%
Diarrhea: 5 people, 38.46%
Pain: 4 people, 30.77%
Pain In Extremity: 4 people, 30.77%
Dizziness: 4 people, 30.77%
Gait Disturbance: 4 people, 30.77%
Fatigue (feeling of tiredness): 4 people, 30.77%
Constipation: 4 people, 30.77%

What are the existing conditions these people have? *

Pain: 4 people, 30.77%
Stress And Anxiety: 2 people, 15.38%
Sleep Disorder: 2 people, 15.38%
Type 2 Diabetes: 1 person, 7.69%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 7.69%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 7.69%
Insomnia (sleeplessness): 1 person, 7.69%
Hypertriglyceridaemia (excess of triglycerides in the blood): 1 person, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.69%
Dyspnea (difficult or laboured breathing): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Zestoretic and have Musculoskeletal stiffness?

- Check whether Musculoskeletal stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestoretic:

Zestoretic (4,342 reports)

Musculoskeletal stiffness treatments and more:

Musculoskeletal stiffness (106,467 reports)

How severe was Musculoskeletal stiffness and when was it recovered:

Musculoskeletal stiffness in Zestoretic

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Musculoskeletal stiffness and drugs with ingredients of hydrochlorothiazide; lisinopril

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zestoretic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,959 drugs)

Browse all the conditions that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,917 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Zestoretic) and Zestoretic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.