Zestoretic and Peripheral swelling - a phase IV clinical study of FDA data

Summary:

Peripheral swelling is reported as a side effect among people who take Zestoretic (hydrochlorothiazide; lisinopril), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Crestor, and have Pain.

The phase IV clinical study analyzes which people have Peripheral swelling when taking Zestoretic. It is created by eHealthMe based on reports of 4,193 people who have side effects when taking Zestoretic from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Peripheral swelling?

Peripheral swelling is found to be associated with 2,182 drugs and 1,743 conditions by eHealthMe. Check the latest studies of Peripheral swelling.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

4,193 people reported to have side effects when taking Zestoretic.
Among them, 30 people (0.72%) have Peripheral swelling.

Could Zestoretic cause Peripheral swelling?

Among these 30 people:

How long have people been on Zestoretic when they have Peripheral swelling? *

What is the gender of people who have Peripheral swelling when taking Zestoretic? *

female: 51.72 %
male: 48.28 %

What is the age of people who have Peripheral swelling when taking Zestoretic? *

What are other drugs people take besides Zestoretic? *

What are other side effects people have besides Peripheral swelling? *

Diarrhea: 15 people, 50.00%
Fatigue (feeling of tiredness): 13 people, 43.33%
Muscle Spasms (muscle contraction): 13 people, 43.33%
Pain In Extremity: 13 people, 43.33%
Cough: 12 people, 40.00%
Dyspnea (difficult or laboured breathing): 11 people, 36.67%
Weight Decreased: 9 people, 30.00%
Headache (pain in head): 9 people, 30.00%
Alanine Aminotransferase Increased: 8 people, 26.67%
Nosebleed (bleeding from nose): 8 people, 26.67%

What are the existing conditions these people have? *

Breast Cancer Metastatic: 6 people, 20.00%
Pain: 6 people, 20.00%
Back Pain: 5 people, 16.67%
Muscle Spasms (muscle contraction): 5 people, 16.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 16.67%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 13.33%
Abdominal Discomfort: 3 people, 10.00%
Constipation: 3 people, 10.00%
Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zestoretic and have Peripheral swelling?

- Check whether Peripheral swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestoretic:

Zestoretic (4,342 reports)

Peripheral swelling treatments and more:

Peripheral swelling (168,738 reports)

How severe was Peripheral swelling and when was it recovered:

Peripheral swelling in Zestoretic

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Peripheral swelling and drugs with ingredients of hydrochlorothiazide; lisinopril (258 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zestoretic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Peripheral swelling:

Peripheral swelling (2,182 drugs)

Browse all the conditions that are associated with Peripheral swelling:

Peripheral swelling (1,743 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Zestoretic) and Zestoretic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.