Zestoretic and Sjs - a phase IV clinical study of FDA data

Summary:

Sjs is reported as a side effect among people who take Zestoretic (hydrochlorothiazide; lisinopril), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Synthroid, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Sjs when taking Zestoretic. It is created by eHealthMe based on reports of 4,193 people who have side effects when taking Zestoretic from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Sjs?

Sjs is found to be associated with 2,450 drugs and 2,910 conditions by eHealthMe. Check the latest studies of Sjs.

On Jul, 01, 2026

4,193 people reported to have side effects when taking Zestoretic.
Among them, 11 people (0.26%) have Sjs.

Among these 11 people:

How long have people been on Zestoretic when they have Sjs? *

What is the gender of people who have Sjs when taking Zestoretic? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Sjs when taking Zestoretic? *

What are other drugs people take besides Zestoretic? *

Synthroid: 4 people, 36.36%
Acetaminophen: 2 people, 18.18%
Cardura: 2 people, 18.18%
Glucotrol Xl: 2 people, 18.18%
Tricor: 2 people, 18.18%
Hydrocortisone Valerate: 2 people, 18.18%
Demadex: 2 people, 18.18%
Deltasone: 2 people, 18.18%
Clotrimazole: 2 people, 18.18%
Glucophage: 2 people, 18.18%

What are other side effects people have besides Sjs? *

Fever: 4 people, 36.36%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 27.27%
Abdominal Pain Upper: 3 people, 27.27%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 27.27%
Diabetes Mellitus Inadequate Control: 3 people, 27.27%
Dyspnea Exertional: 2 people, 18.18%
Lymphocyte Count Decreased: 2 people, 18.18%
Itching: 2 people, 18.18%
Insomnia (sleeplessness): 2 people, 18.18%
Hepatorenal Syndrome (renal failure in patients with advanced chronic liver disease): 2 people, 18.18%

What are the existing conditions these people have? *

High Blood Cholesterol: 2 people, 18.18%
Type 2 Diabetes: 1 person, 9.09%
Tumor: 1 person, 9.09%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 1 person, 9.09%
Otitis Media (inflammation of the middle ear): 1 person, 9.09%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 9.09%
Dermatosis (a disease of the skin, esp. one that does not cause inflammation): 1 person, 9.09%
Brain Neoplasm (tumour of brain): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Zestoretic and have Sjs?

- Check whether Sjs is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestoretic:

Zestoretic (4,342 reports)

Sjs treatments and more:

Sjs (56,072 reports)

How severe was Sjs and when was it recovered:

Sjs in Zestoretic

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Sjs and drugs with ingredients of hydrochlorothiazide; lisinopril (45 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zestoretic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sjs:

Sjs (2,450 drugs)

Browse all the conditions that are associated with Sjs:

Sjs (2,910 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Zestoretic) and Zestoretic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.