Zide and Complex partial seizures exacerbated - a phase IV clinical study of FDA data

Summary:

Complex partial seizures exacerbated is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 40-49 old, also take Lisinopril, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Complex partial seizures exacerbated when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Complex partial seizures exacerbated?

Complex partial seizures exacerbated (type of seizure in epilepsy) is found to be associated with 202 drugs and 247 conditions by eHealthMe. Check the latest studies of Complex partial seizures exacerbated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 12 people (0.01%) have Complex partial seizures exacerbated.

Could Zide cause Complex partial seizures exacerbated?

Among these 12 people:

What is the gender of people who have Complex partial seizures exacerbated when taking Zide? *

female: 75 %
male: 25 %

What is the age of people who have Complex partial seizures exacerbated when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Complex partial seizures exacerbated? *

Oedema Peripheral (superficial swelling): 2 people, 16.67%
Migraine (headache): 2 people, 16.67%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 16.67%
Weight Loss: 2 people, 16.67%
Dyspnea (difficult or laboured breathing): 2 people, 16.67%
Drowsiness: 2 people, 16.67%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 2 people, 16.67%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 2 people, 16.67%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 16.67%
Cough: 2 people, 16.67%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 16.67%
Sleep Disorder: 1 person, 8.33%
Sleep Apnea Syndrome: 1 person, 8.33%
Salivary Hypersecretion (excess saliva secretion): 1 person, 8.33%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 8.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 8.33%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 8.33%
Pain: 1 person, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 8.33%
High Blood Cholesterol: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Complex partial seizures exacerbated?

- Check whether Complex partial seizures exacerbated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Complex partial seizures exacerbated:

Complex partial seizures exacerbated (202 drugs)

Browse all the conditions that are associated with Complex partial seizures exacerbated:

Complex partial seizures exacerbated (247 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.