Zide and Cystoid macular oedema - a phase IV clinical study of FDA data

Summary:

Cystoid macular oedema is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 60+ old, also take Avastin, and have Diabetic eye disease.

The phase IV clinical study analyzes which people have Cystoid macular oedema when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Cystoid macular oedema?

Cystoid macular oedema (fluid accumulation after cataract surgery) is found to be associated with 150 drugs and 279 conditions by eHealthMe. Check the latest studies of Cystoid macular oedema.

On Jul, 08, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 11 people (0.01%) have Cystoid macular oedema.

Could Zide cause Cystoid macular oedema?

Among these 11 people:

What is the gender of people who have Cystoid macular oedema when taking Zide? *

female: 60 %
male: 40 %

What is the age of people who have Cystoid macular oedema when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Cystoid macular oedema? *

Vision Blurred: 6 people, 54.55%
Visual Acuity Reduced (reduced clearness of vision): 5 people, 45.45%
Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 4 people, 36.36%
Vitreous Floaters (spots before the eyes): 3 people, 27.27%
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest): 2 people, 18.18%
Musculoskeletal Disorder (disease of the body's muscles, joints, tendons, ligaments and nerves): 2 people, 18.18%
Aneurysm (enlargement of an artery caused by a weakening of the artery wall): 2 people, 18.18%
Arthropathy: 2 people, 18.18%
Conjunctivitis (pink eye): 2 people, 18.18%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 2 people, 18.18%

What are the existing conditions these people have? *

Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 5 people, 45.45%
Diabetic Eye Disease: 5 people, 45.45%
Mydriasis (a dilation of the pupil): 4 people, 36.36%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 4 people, 36.36%
Retinal Oedema (swelling of retina): 2 people, 18.18%
Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 2 people, 18.18%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 1 person, 9.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 9.09%
Eye Pain: 1 person, 9.09%
Eye Inflammation: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Cystoid macular oedema?

- Check whether Cystoid macular oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cystoid macular oedema:

Cystoid macular oedema (150 drugs)

Browse all the conditions that are associated with Cystoid macular oedema:

Cystoid macular oedema (279 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.