Zide and Dry eye syndrome - a phase IV clinical study of FDA data

Summary:

Dry eye syndrome is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are male, 60+ old, also take Lipitor, and have Essential hypertension.

The phase IV clinical study analyzes which people have Dry eye syndrome when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Dry eye syndrome?

Dry eye syndrome is found to be associated with 230 drugs and 700 conditions by eHealthMe. Check the latest studies of Dry eye syndrome.

On Apr, 22, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 17 people (0.01%) have Dry eye syndrome.

Among these 17 people:

What is the gender of people who have Dry eye syndrome when taking Zide? *

female: 30.77 %
male: 69.23 %

What is the age of people who have Dry eye syndrome when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Dry eye syndrome? *

Back Pain: 8 people, 47.06%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 8 people, 47.06%
Cataract (clouding of the lens inside the eye): 7 people, 41.18%
Tendonitis (a condition that causes pain and swelling of tendons): 7 people, 41.18%
Dyspnea (difficult or laboured breathing): 6 people, 35.29%
Hypoaesthesia (reduced sense of touch or sensation): 6 people, 35.29%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 35.29%
Glaucoma (increased fluid pressure in the eye with vision loss): 6 people, 35.29%
Upper Respiratory Tract Infection: 6 people, 35.29%
Inflammation: 6 people, 35.29%

What are the existing conditions these people have? *

Essential Hypertension (primary hypertension): 3 people, 17.65%
Depression: 2 people, 11.76%
Prostate Cancer: 2 people, 11.76%
Pain: 2 people, 11.76%
Vulvovaginal Dryness: 1 person, 5.88%
High Blood Cholesterol: 1 person, 5.88%
Cardiac Disorder: 1 person, 5.88%
Constipation: 1 person, 5.88%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 5.88%
Gastric Disorder (disease of stomach): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Dry eye syndrome?

- Check whether Dry eye syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dry eye syndrome:

Dry eye syndrome (230 drugs)

Browse all the conditions that are associated with Dry eye syndrome:

Dry eye syndrome (700 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.