Zide and Gallbladder attack - a phase IV clinical study of FDA data

Summary:

Gallbladder attack is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 60+ old, also take Yaz, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Gallbladder attack when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,221 Zide users. Check the latest studies of Zide.

What is Gallbladder attack?

Gallbladder attack (gallstones, gallbladder disease and gallbladder pain) is found to be associated with 692 drugs and 970 conditions by eHealthMe. Check the latest studies of Gallbladder attack.

On Oct, 22, 2025

178,473 people reported to have side effects when taking Zide.
Among them, 56 people (0.03%) have Gallbladder attack.

Among these 56 people:

What is the gender of people who have Gallbladder attack when taking Zide? *

female: 74.55 %
male: 25.45 %

What is the age of people who have Gallbladder attack when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Gallbladder attack? *

Abdominal Pain: 23 people, 41.07%
Chest Pain: 16 people, 28.57%
Cholecystitis Chronic (long lasting infection of gallbladder): 15 people, 26.79%
Gallstones (stone formation by bile component): 14 people, 25.00%
Nasopharyngitis (inflammation of the nasopharynx): 14 people, 25.00%
Nausea (feeling of having an urge to vomit): 13 people, 23.21%
Nausea And Vomiting: 12 people, 21.43%
Blood Pressure Systolic Increased: 9 people, 16.07%
Productive Cough: 9 people, 16.07%
Canker Sores (painful, open sore in the mouth): 9 people, 16.07%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 17.86%
Immunodeficiency: 6 people, 10.71%
Depression: 5 people, 8.93%
Premenstrual Syndrome: 5 people, 8.93%
Immunodeficiency Common Variable: 5 people, 8.93%
Birth Control: 5 people, 8.93%
Cushing's Syndrome (obesity, a rounded face, increased fat): 4 people, 7.14%
Blood Uric Acid Abnormal: 4 people, 7.14%
Menstrual Disorder (disease of menstrual cycle): 3 people, 5.36%
Diabetes: 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Gallbladder attack?

- Check whether Gallbladder attack is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,221 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder attack:

Gallbladder attack (692 drugs)

Browse all the conditions that are associated with Gallbladder attack:

Gallbladder attack (970 conditions)

Drugs similar to Zide and Gallbladder attack :

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.