Zide and Hyperacusis - a phase IV clinical study of FDA data

Summary:

Hyperacusis is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 50-59 old, also take Paxil, and have Headache.

The phase IV clinical study analyzes which people have Hyperacusis when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,231 Zide users. Check the latest studies of Zide.

What is Hyperacusis?

Hyperacusis (disorder in loudness perception) is found to be associated with 445 drugs and 603 conditions by eHealthMe. Check the latest studies of Hyperacusis.

On Jan, 13, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 34 people (0.02%) have Hyperacusis.

Among these 34 people:

What is the gender of people who have Hyperacusis when taking Zide? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Hyperacusis when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Hyperacusis? *

Nausea (feeling of having an urge to vomit): 19 people, 55.88%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 15 people, 44.12%
Dizziness: 13 people, 38.24%
Headache (pain in head): 12 people, 35.29%
Memory Loss: 11 people, 32.35%
Drug Ineffective: 11 people, 32.35%
Stress And Anxiety: 10 people, 29.41%
Photophobia (extreme sensitivity to light): 9 people, 26.47%
Tinnitus (a ringing in the ears): 9 people, 26.47%
Nausea And Vomiting: 9 people, 26.47%

What are the existing conditions these people have? *

Headache (pain in head): 10 people, 29.41%
Menstruation Irregular: 6 people, 17.65%
Stress And Anxiety: 5 people, 14.71%
Depression: 5 people, 14.71%
Panic Disorder: 4 people, 11.76%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 8.82%
Pain: 3 people, 8.82%
Androgen Deficiency: 2 people, 5.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 5.88%
Thyroid Diseases: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Hyperacusis?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,231 reports)

Hyperacusis treatments and more:

Hyperacusis (4,388 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperacusis:

Hyperacusis (445 drugs)

Browse all the conditions that are associated with Hyperacusis:

Hyperacusis (603 conditions)

Drugs similar to Zide and Hyperacusis :

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.