Zide and Hypospadias - a phase IV clinical study of FDA data

Summary:

Hypospadias is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are 0-1 old, have been taking the drug for 1 - 6 months also take Novorapid, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Hypospadias when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Hypospadias?

Hypospadias (an abnormal condition in males in which the urethra opens on the under surface of the penis) is found to be associated with 138 drugs and 59 conditions by eHealthMe. Check the latest studies of Hypospadias.

On Jul, 16, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 27 people (0.02%) have Hypospadias.

Among these 27 people:

How long have people been on Zide when they have Hypospadias? *

What is the age of people who have Hypospadias when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Hypospadias? *

Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 18 people, 66.67%
Hypoacusis (loss of hearing): 12 people, 44.44%
Premature Baby: 5 people, 18.52%
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 4 people, 14.81%
Cerebral Infarction (less blood supply to brain resulting tissue damage): 4 people, 14.81%
Foetal Growth Restriction (poor growth of a baby while in the mother's womb during pregnancy): 3 people, 11.11%
Partial Seizures (seizures which affect only a part of the brain at onset): 3 people, 11.11%
Pulmonary Valve Stenosis (heart valve disorder in which outflow of blood from the right ventricle of the heart is obstructed at the level of the pulmonic valve): 2 people, 7.41%
Low Birth Weight Baby: 2 people, 7.41%
Feeding Disorder Neonatal (when newborn refuse to drink milk): 2 people, 7.41%

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 22.22%
Type 1 Diabetes: 4 people, 14.81%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 4 people, 14.81%
Acute Stress Disorder: 4 people, 14.81%
Ultrasound Doppler Abnormal: 1 person, 3.70%
Quit Smoking: 1 person, 3.70%
Pain: 1 person, 3.70%
Multiple Myeloma (cancer of the plasma cells): 1 person, 3.70%
Gestational Diabetes (diabetes in pregnancy): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Hypospadias?

- Check whether Hypospadias is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Hypospadias treatments and more:

Hypospadias (2,613 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypospadias:

Hypospadias (138 drugs)

Browse all the conditions that are associated with Hypospadias:

Hypospadias (59 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.