Zide and Metabolic encephalopathy - a phase IV clinical study of FDA data

Summary:

Metabolic encephalopathy is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Janumet, and have Diabetes.

The phase IV clinical study analyzes which people have Metabolic encephalopathy when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Metabolic encephalopathy?

Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy) is found to be associated with 552 drugs and 587 conditions by eHealthMe. Check the latest studies of Metabolic encephalopathy.

On Jul, 05, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 78 people (0.04%) have Metabolic encephalopathy.

Could Zide cause Metabolic encephalopathy?

Among these 78 people:

How long have people been on Zide when they have Metabolic encephalopathy? *

What is the gender of people who have Metabolic encephalopathy when taking Zide? *

female: 69.01 %
male: 30.99 %

What is the age of people who have Metabolic encephalopathy when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Metabolic encephalopathy? *

Hypokalemia (low potassium): 12 people, 15.38%
Hypoglycemia (low blood sugar): 12 people, 15.38%
Weakness: 11 people, 14.10%
Fall: 10 people, 12.82%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 10 people, 12.82%
Acute Kidney Failure: 9 people, 11.54%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 9 people, 11.54%
Diarrhea: 9 people, 11.54%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 9 people, 11.54%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 8 people, 10.26%

What are the existing conditions these people have? *

Diabetes: 16 people, 20.51%
Dyslipidaemia (abnormal amount of lipids): 11 people, 14.10%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 7 people, 8.97%
Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 7.69%
Stress And Anxiety: 6 people, 7.69%
Oedema Peripheral (superficial swelling): 6 people, 7.69%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 6 people, 7.69%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 6.41%
Immunodeficiency Disorders: 4 people, 5.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Metabolic encephalopathy?

- Check whether Metabolic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Metabolic encephalopathy:

Metabolic encephalopathy (552 drugs)

Browse all the conditions that are associated with Metabolic encephalopathy:

Metabolic encephalopathy (587 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.