Zide and Nephropathy toxic - a phase IV clinical study of FDA data

Summary:

Nephropathy toxic is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Acetylsalicylic Acid, and have Psoriasis.

The phase IV clinical study analyzes which people have Nephropathy toxic when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Nephropathy toxic?

Nephropathy toxic (damage to kidney due to toxins) is found to be associated with 596 drugs and 738 conditions by eHealthMe. Check the latest studies of Nephropathy toxic.

On Aug, 04, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 91 people (0.05%) have Nephropathy toxic.

Among these 91 people:

How long have people been on Zide when they have Nephropathy toxic? *

What is the gender of people who have Nephropathy toxic when taking Zide? *

female: 54.67 %
male: 45.33 %

What is the age of people who have Nephropathy toxic when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Nephropathy toxic? *

Acute Kidney Failure: 18 people, 19.78%
Bone Marrow Failure: 15 people, 16.48%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 13 people, 14.29%
Sepsis (a severe blood infection that can lead to organ failure and death): 13 people, 14.29%
Skin Erosion (a discontinuity of the skin): 12 people, 13.19%
Procalcitonin Increased: 11 people, 12.09%
C-Reactive Protein Increased: 11 people, 12.09%
Thrombocytopenia (decrease of platelets in blood): 11 people, 12.09%
Renal Impairment (severely reduced kidney function): 10 people, 10.99%
Fall: 8 people, 8.79%

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 16 people, 17.58%
Joint Pain: 6 people, 6.59%
Diabetes: 5 people, 5.49%
High Blood Cholesterol: 4 people, 4.40%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 4.40%
Hiv Infection: 4 people, 4.40%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 4.40%
Bipolar Disorder (mood disorder): 3 people, 3.30%
Pain: 3 people, 3.30%
Staphylococcal Osteomyelitis (inflammation of bone or bone marrow, usually due to staphylococcus bacterial infection): 3 people, 3.30%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Nephropathy toxic?

- Check whether Nephropathy toxic is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nephropathy toxic:

Nephropathy toxic (596 drugs)

Browse all the conditions that are associated with Nephropathy toxic:

Nephropathy toxic (738 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.