Zide and Skin nodule - a phase IV clinical study of FDA data

Summary:

Skin nodule is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 60+ old, also take Prednisone, and have Breast cancer.

The phase IV clinical study analyzes which people have Skin nodule when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Skin nodule?

Skin nodule (slightly elevated lesions on or in the skin) is found to be associated with 142 drugs and 280 conditions by eHealthMe. Check the latest studies of Skin nodule.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 15 people (0.01%) have Skin nodule.

Among these 15 people:

What is the gender of people who have Skin nodule when taking Zide? *

female: 73.33 %
male: 26.67 %

What is the age of people who have Skin nodule when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Skin nodule? *

Skin Ulcer: 2 people, 13.33%
Muscle Aches (muscle pain): 2 people, 13.33%
Weight Increased: 1 person, 6.67%
Intracardiac Thrombus (presence of a circumscribed mass with heart wall): 1 person, 6.67%
Bifascicular Block (conduction abnormality in the heart where two of the three main fascicles of the his/purkinje system are blocked): 1 person, 6.67%
Bundle Branch Block (disruption in the normal flow of electrical pulses that drive the heart beat): 1 person, 6.67%
Dehydration (dryness resulting from the removal of water): 1 person, 6.67%
Drug Hypersensitivity: 1 person, 6.67%
Enlarged Heart: 1 person, 6.67%
Erythema Multiforme (a type of hypersensitivity reaction): 1 person, 6.67%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 20.00%
Breast Cancer: 3 people, 20.00%
Pain: 1 person, 6.67%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 1 person, 6.67%
Malignant Melanoma Stage Iv (the cancer has spread to other places in the body, such as the lung, liver, brain, bone, soft tissue, or gastrointestinal (gi) tract. cancer may have spread to places in the skin far away from where it first started): 1 person, 6.67%
Ill-Defined Disorder: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Skin nodule?

- Check whether Skin nodule is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Skin nodule treatments and more:

Skin nodule (1,166 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin nodule:

Skin nodule (142 drugs)

Browse all the conditions that are associated with Skin nodule:

Skin nodule (280 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.