Zide and Systemic sclerosis (scleroderma) - a phase IV clinical study of FDA data

Summary:

Systemic sclerosis (scleroderma) is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Norvasc, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Systemic sclerosis (scleroderma) when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Systemic sclerosis (scleroderma)?

Systemic sclerosis (scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin) is found to be associated with 495 drugs and 857 conditions by eHealthMe. Check the latest studies of Systemic sclerosis (scleroderma).

On Jul, 15, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 47 people (0.03%) have Systemic sclerosis (scleroderma).

Could Zide cause Systemic sclerosis (scleroderma)?

Among these 47 people:

How long have people been on Zide when they have Systemic sclerosis (scleroderma)? *

What is the gender of people who have Systemic sclerosis (scleroderma) when taking Zide? *

female: 85.11 %
male: 14.89 %

What is the age of people who have Systemic sclerosis (scleroderma) when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Systemic sclerosis (scleroderma)? *

Weakness: 14 people, 29.79%
Joint Pain: 14 people, 29.79%
Stress And Anxiety: 11 people, 23.40%
Pain In Extremity: 11 people, 23.40%
Pain: 10 people, 21.28%
Oedema Peripheral (superficial swelling): 10 people, 21.28%
Hypoaesthesia (reduced sense of touch or sensation): 10 people, 21.28%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 9 people, 19.15%
Fatigue (feeling of tiredness): 8 people, 17.02%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 17.02%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 21.28%
Depression: 5 people, 10.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.64%
Platelet Count Increased: 5 people, 10.64%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 8.51%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 8.51%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 3 people, 6.38%
Muscle Spasms (muscle contraction): 3 people, 6.38%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 6.38%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Systemic sclerosis (scleroderma)?

- Check whether Systemic sclerosis (scleroderma) is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (495 drugs)

Browse all the conditions that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (857 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.