Zide and Ttp - a phase IV clinical study of FDA data

Summary:

Ttp is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are male, 60+ old, also take Celebrex, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Ttp when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,221 Zide users. Check the latest studies of Zide.

What is Ttp?

Ttp is found to be associated with 985 drugs and 819 conditions by eHealthMe. Check the latest studies of Ttp.

On Oct, 13, 2025

178,473 people reported to have side effects when taking Zide.
Among them, 75 people (0.04%) have Ttp.

Among these 75 people:

What is the gender of people who have Ttp when taking Zide? *

female: 48.65 %
male: 51.35 %

What is the age of people who have Ttp when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Ttp? *

Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 42 people, 56.00%
Fatigue (feeling of tiredness): 41 people, 54.67%
Dyspnea (difficult or laboured breathing): 40 people, 53.33%
Oral Pain: 39 people, 52.00%
Bone Disorder: 39 people, 52.00%
Anaemia (lack of blood): 38 people, 50.67%
Thrombocytopenia (decrease of platelets in blood): 38 people, 50.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 37 people, 49.33%
Diarrhea: 37 people, 49.33%
Cough: 37 people, 49.33%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 33 people, 44.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 26 people, 34.67%
Diarrhea: 25 people, 33.33%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 25 people, 33.33%
High Blood Cholesterol: 25 people, 33.33%
Mood Swings (an extreme or rapid change in mood): 25 people, 33.33%
Joint Pain: 25 people, 33.33%
Seasonal Allergy (allergic condition due to certain season): 18 people, 24.00%
Blood Triglycerides Decreased: 18 people, 24.00%
Breast Cancer: 8 people, 10.67%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Ttp?

- Check whether Ttp is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,221 reports)

Ttp treatments and more:

Ttp (6,447 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ttp:

Ttp (985 drugs)

Browse all the conditions that are associated with Ttp:

Ttp (819 conditions)

Drugs similar to Zide and Ttp :

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.